Defining Hormesis: Evaluation of a Complex Concentration Response Phenomenon
Defining Hormesis: Evaluation of a Complex Concentration Response Phenomenon
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DOI：
10.1177/1091581810363012
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发表时间：
2010-05-01
影响因子：
2.2
通讯作者：
Belcher, Scott M.
中科院分区：
文献类型：
--
作者：
Kendig, Eric L.;Le, Hoa H.;Belcher, Scott M.
毒物兴奋效应描述了剂量反应关系，其特征是低剂量和高剂量的化学物质、生物分子、物理应激源或其他反应引发剂之间的反应逆转。直到最近，毒物兴奋效应作为一种可行的剂量反应理论的接受度还受到限制，部分原因是概念理解不佳、临时和不恰当的使用以及缺乏明确的机制。通过研究这种剂量反应理论的历史，很明显，药理学和毒理学研究都为毒物兴奋剂剂量反应提供了证据，但研究的回顾性检查充其量也可能是有问题的。有限的科学证据和缺乏描述这些反应的通用词汇使得毒物兴奋效应容易不适当地应用于不相关的剂量反应关系。未来的研究应该使用公正的描述性标准来检查低剂量效应，以进一步科学地理解这种剂量反应。需要一个清晰、简明的定义来进一步证明毒物兴奋剂剂量反应的有限科学证据。
Hormesis describes dose-response relationships characterized by a reversal of response between low and high doses of chemicals, biological molecules, physical stressors, or other initiators of a response. Acceptance of hormesis as a viable dose-response theory has been limited until recently, in part, because of poor conceptual understanding, ad hoc and inappropriate use, and lack of a defined mechanism. By examining the history of this dose-response theory, it is clear that both pharmacological and toxicological studies provide evidence for hormetic dose responses, but retrospective examination of studies can be problematic at best. Limited scientific evidence and lack of a common lexicon with which to describe these responses have left hormesis open to inappropriate application to unrelated dose-response relationships. Future studies should examine low-dose effects using unbiased, descriptive criteria to further the scientific understanding of this dose response. A clear, concise definition is required to further the limited scientific evidence for hormetic dose responses.