Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases
Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases
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DOI：
10.15420/ecr.2019.17.2
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发表时间：
2019-03
影响因子：
3
通讯作者：
Kana Shimizu;Masafumi Funamoto;Yoichi Sunagawa;Satoshi Shimizu;Y. Katanasaka;Yusuke Miyazaki;H. Wada;K. Hasegawa;T. Morimoto
中科院分区：
文献类型：
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作者：
Kana Shimizu;Masafumi Funamoto;Yoichi Sunagawa;Satoshi Shimizu;Y. Katanasaka;Yusuke Miyazaki;H. Wada;K. Hasegawa;T. Morimoto
慢性炎症在生活方式相关疾病中起重要作用，如心血管疾病和肥胖/葡萄糖耐量受损。姜黄素是一种天然提取物，具有许多生理特性，如其抗炎作用所示。这些作用的潜在机制包括抑制核因子-κ B和Toll样受体4依赖性信号传导途径以及激活过氧化物酶体增殖物激活受体-γ途径。然而，姜黄素在人体中的生物利用度非常低。为了解决这个问题，已经开发了几种药物递送系统，并且许多临床试验已经报道了姜黄素在炎症相关疾病的管理中的有益作用。预计有关姜黄素在与慢性炎症相关的生活方式相关疾病中的临床应用的证据将随着时间的推移而积累。
Chronic inflammation plays a significant role in lifestyle-related diseases, such as cardiovascular diseases and obesity/impaired glucose tolerance. Curcumin is a natural extract that possesses numerous physiological properties, as indicated by its anti-inflammatory action. The mechanisms underlying these effects include the inhibition of nuclear factor-kappaB and Toll-like receptor 4-dependent signalling pathways and the activation of a peroxisome proliferator-activated receptor-gamma pathway. However, the bioavailability of curcumin is very low in humans. To resolve this issue, several drug delivery systems have been developed and a number of clinical trials have reported beneficial effects of curcumin in the management of inflammation-related diseases. It is expected that evidence regarding the clinical application of curcumin in lifestyle-related diseases associated with chronic inflammation will accumulate over time.