In vivo studies on Mg-1Sc alloy for orthopedic application: A 5-months evaluation in rabbits
In vivo studies on Mg-1Sc alloy for orthopedic application: A 5-months evaluation in rabbits
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用于骨科应用的 Mg-1Sc 合金的体内研究：对兔子进行 5 个月的评估
DOI：
10.1016/j.matlet.2019.127130
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发表时间：
2020-03-01
影响因子：
3
通讯作者：
Zheng, Yufeng
中科院分区：
文献类型：
--
作者：
Lin, Yulin;Liu, Jianing;Zheng, Yufeng
通过体内植入兔股骨干，研究了Mg-1Sc合金作为骨科植入物的可行性。 Mg-154x Sc合金的体内腐蚀率为0.60+/-0.06mm.y(-1)。 Mg-1Sc合金可以保持其结构和机械完整性超过5个月。与Ti6Al4V合金相比，Mg-ISc表现出更好的成骨作用。腐蚀产物主要由Mg(OH)(2)、MgCO3中心点3H(2)O和磷酸钙组成，不会产生毒性作用。总的来说，Mg-1Sc合金良好的体内降解率和优异的成骨作用表明它可能是可生物降解骨科植入物的有前途的候选者。 (C) 2019 Elsevier B.V. 保留所有权利。
The feasibility of Mg-1Sc alloy as orthopedic implant was studied by in vivo implantation into femur shaft of rabbit. The in vivo corrosion rate of Mg-154x Sc alloy was 0.60 +/- 0.06 mm.y(-1). Mg-1Sc alloy could maintain its structural and mechanical integrity for more than 5 months. Compared with Ti6Al4V alloy, Mg-ISc showed better osteogenesis. The corrosion products were mainly composed of Mg(OH)(2) , MgCO3 center dot 3H(2)O and calcium phosphate, which would not induce toxic effect. In general, the decent degradation rate in vivo and superior osteogenesis of Mg-1Sc alloy indicate that it may be a promising candidate for biodegradable orthopedic implants. (C) 2019 Elsevier B.V. All rights reserved.