Inflammatory mammary carcinoma in dogs:: 33 cases (1995-1999)
Inflammatory mammary carcinoma in dogs:: 33 cases (1995-1999)
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DOI：
10.2460/javma.2001.219.1110
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发表时间：
2001-10-15
期刊：
影响因子：
--
通讯作者：
Peña, L
中科院分区：
文献类型：
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作者：
Alenza, MDP;Tabanera, E;Peña, L
目的：探讨犬炎性乳腺癌（IC）的流行病学、临床和病理特征。设计回顾性研究。实验动物：33只IC犬和153只非IC恶性乳腺肿瘤犬。方法：回顾医疗记录，获得信号、病史、体格检查结果、胸部x线片和尸检结果。结果：在某兽医教学医院检查的436只犬中有33只（7.6%）患有乳腺发育不良或肿瘤，186只至少有1个恶性肿瘤的犬中有33只（17.7%）患有IC，其中32只犬性完整。患有IC的狗明显比患有其他恶性乳腺肿瘤的狗年龄大，并且在患有IC的狗中，肿瘤最初发现的平均时间是在最后一次观察到的发情开始后的52天，而在患有其他乳腺肿瘤的狗中，肿瘤最初发现的平均时间是在最后一次观察到的发情开始后的137天。患有IC的狗更有可能出现厌食、全身无力、体重减轻和胸部转移。患有IC的狗在姑息治疗下平均存活了25天。组织学上，19只IC犬中有14只（74%）发现真皮淋巴管受累。确定了两种临床形式（原发性和继发性）IC。原发性IC犬的临床状况更差。结论和临床意义：结果表明，IC在犬中是一种罕见但独特的实体。真皮淋巴受累的组织学发现应被认为是犬IC病理诊断的标志。
Objective-To determine epidemiologic, clinical, and pathologic characteristics of inflammatory mammary carcinoma (IC) in dogs.Design-Retrospective study.Animals-33 dogs with IC and 153 dogs with malignant mammary tumors other than IC.Procedures-Medical records were reviewed, and signalment, history, physical examination findings, and results of thoracic radiography and necropsy were obtained. Results-33 of 436 (7.6%) dogs examined at a veterinary teaching hospital because of dysplasia or tumors of the mammary glands and 33 of 186 (17.7%) dogs with at least 1 malignant tumor had IC. Thirty-two of the 33 dogs were sexually intact. Dogs with IC were significantly older than were dogs with other malignant mammary tumors, and in dogs with IC, the tumor was initially noticed a mean of 52 days after the beginning of the last observed estrus, whereas in dogs with other mammary tumors, the tumor was initially noticed a mean of 137 days after the beginning of the last observed estrus. Dogs with IC were more likely to be anorectic and to have generalized weakness, weight loss, and thoracic metastases. Dogs with IC survived a mean of 25 days with palliative treatment. Histologically, involvement of dermal lymphatic vessels was identified in 14 of 19 (74%) dogs with IC. Two clinical forms of IC (primary and secondary) were identified. Dogs with primary IC had a worse clinical condition.Conclusions and Clinical Relevance-Results suggest that IC is an uncommon but distinct entity in dogs. A histologic finding of dermal lymphatic involvement should be considered a hallmark for the pathologic diagnosis of IC in dogs.