Chronic psychological stress induces the accumulation of myeloid-derived suppressor cells in mice.
Chronic psychological stress induces the accumulation of myeloid-derived suppressor cells in mice.
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DOI：
10.1371/journal.pone.0074497
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Jin J;Wang X;Wang Q;Guo X;Cao J;Zhang X;Zhu T;Zhang D;Wang W;Wang J;Shen B;Gao X;Shi Y;Zhang J
慢性心理压力已被证明会对免疫系统功能产生不利影响，并损害宿主对各种感染的防御能力。然而，潜在的机制仍然难以捉摸。最近的研究表明，骨髓源性抑制细胞（MDSC）在调节免疫方面发挥着重要作用。探讨慢性心理应激是否部分通过诱导MDSCs积累而发挥免疫抑制功能是很有意义的。在这项工作中，我们报告慢性心理压力导致 BALB/c 小鼠骨髓中 CD11b+Gr1+ 细胞的积累。重复输注β-激动剂没有显示出这样的效果。然而，在慢性心理应激条件下，β-肾上腺素能阻断部分逆转了CD11b+Gr1+细胞的积累，而糖皮质激素阻断则不然，这表明儿茶酚胺与其他因素共同诱导了CD11b+Gr1+细胞的积累。进一步的探索表明环加氧酶 2 (COX-2)-前列腺素 E2 (PGE2) 环可能在下游起作用以诱导积累。大多数积累的 CD11b+Gr1+ 细胞是 Ly6G+Ly6Clow 未成熟中性粒细胞，它抑制巨噬细胞的细胞因子释放以及 T 细胞反应性。此外，慢性心理应激条件下积累的CD11b+Gr1+细胞表达多种抑制分子。总而言之，我们的数据首次证明，慢性心理压力会诱导小鼠 MDSC 积累，从而导致免疫抑制。
Chronic psychological stress has been shown to adversely impact immune system functions and compromise host defenses against various infections. However, the underlying mechanisms remain elusive. Recent studies have demonstrated that myeloid-derived suppressor cells (MDSCs) play an important role in regulating immunity. It is of interest to explore whether or not chronic psychological stress plays immunosuppressive functions partially by inducing MDSCs accumulation. In this work, we report that chronic psychological stress led to the accumulation of CD11b+Gr1+ cells in the bone marrow of BALB/c mice. Repeated β-agonist infusion showed no such effect. However, β-adrenergic blockade, but not glucocorticoids blockade, partially reversed the accumulation of CD11b+Gr1+ cells under the condition of chronic psychological stress, suggesting catecholamines collaborate with other factors to induce the accumulation. Further exploration indicates that cyclooxygenase 2 (COX-2)-prostaglandin E2 (PGE2) loop might act downstream to induce the accumulation. A majority of the accumulated CD11b+Gr1+ cells were Ly6G+Ly6Clow immature neutrophils, which inhibited cytokine release of macrophages as well as T cell responsiveness. Moreover, the accumulated CD11b+Gr1+ cells under the condition of chronic psychological stress expressed multiple inhibitory molecules. Taken together, our data demonstrate for the first time that chronic psychological stress induces MDSCs accumulation in mice, which can contribute to immunosuppression.
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DOI：
10.1084/jem.20091474
发表时间：
2010-07-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Sander LE;Sackett SD;Dierssen U;Beraza N;Linke RP;Müller M;Blander JM;Tacke F;Trautwein C
通讯作者：
Trautwein C
DOI：
10.1073/pnas.1203930109
发表时间：
2012-05-01
影响因子：
11.1
作者：
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通讯作者：
Hu, Wenwei
影响因子：
8
作者：
Jiang, XH;Lam, SK;Wong, BCY
通讯作者：
Wong, BCY
影响因子：
7.7
作者：
Robertson, RP
通讯作者：
Robertson, RP
影响因子：
20.3
作者：
Obermajer, Natasa;Muthuswamy, Ravikumar;Kalinski, Pawel
通讯作者：
Kalinski, Pawel