Base excision repair in nucleosome substrates
Base excision repair in nucleosome substrates
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DOI：
10.1007/s10577-005-1020-7
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发表时间：
2006-02-01
影响因子：
2.6
通讯作者：
Hayes, JJ
中科院分区：
文献类型：
--
作者：
Jagannathan, I;Cole, HA;Hayes, JJ
真核细胞必须在染色质内修复DNA损伤。我们目前对参与DNA修复过程的酶活性的理解大部分来自利用裸DNA作为底物的体外研究。在这里，我们回顾目前的文献调查如何参与碱基切除修复（BER）的酶与核小体底物竞争，并讨论的可能性，BER中涉及的一些活动是兼容的组织内的DNA核小体。此外，我们还研究了辅助因子（如组蛋白修饰酶）的作用以及组蛋白尾部结构域在调节BER因子对核小体底物的活性中的作用的证据。
Eukaryotic cells must repair DNA lesions within the context of chromatin. Much of our current understanding regarding the activity of enzymes involved in DNA repair processes comes from in-vitro studies utilizing naked DNA as a substrate. Here we review current literature investigating how enzymes involved in base excision repair (BER) contend with nucleosome substrates, and discuss the possibility that some of the activities involved in BER are compatible with the organization of DNA within nucleosomes. In addition, we examine evidence for the role of accessory factors, such as histone modification enzymes, and the role of the histone tail domains in moderating the activities of BER factors on nucleosomal substrates.