TCF7L2 genetic variants modulate the effect of dietary fat intake on changes in body composition during a weight-loss intervention
TCF7L2 genetic variants modulate the effect of dietary fat intake on changes in body composition during a weight-loss intervention
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DOI：
10.3945/ajcn.112.038125
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发表时间：
2012-11-01
影响因子：
7.1
通讯作者：
Qi, Lu
中科院分区：
文献类型：
--
作者：
Mattei, Josiemer;Qi, Qibin;Qi, Lu
背景：TCF7L2基因变异与2型糖尿病和肥胖症的风险增加有关。观察性研究和短期试验表明，大量营养素可能会改变这些影响。目的：在长期干预环境中，我们调查了TCF7L2基因rs7903146和rs12255372多态和膳食总脂肪对身体成分变化和随后的血糖控制的影响。设计：分析了591名参与新型饮食策略预防超重试验的数据，该试验是一项为期两年的随机减肥临床试验，饮食中大量营养素的比例不同。与高脂饮食(40%来自能量)相比，低脂饮食(20%来自能量)的基因主效应和相互作用获得了6个月和24个月身体成分变化的调整平均值。还测试了与蛋白质和碳水化合物摄入量之间的相互作用。结果：rs12255372TT(危险基因)和脂肪摄入量在6个月时对BMI、总脂肪质量和躯干脂肪质量(均P/Q<；0.05)的变化存在显著的交互作用，而低脂饮食的TT携带者的降幅并不显著。在24个月或其他常量营养素没有观察到显著的相关性。结论：携带TCF7L2 rs12255372风险基因的个体可通过饮食中总脂肪含量较低的饮食来降低体脂水平，从而降低体脂水平。这些减少可能会导致更好的血糖控制对这类易患2型糖尿病的人。这项减磅试验在Clinicaltrials.gov上注册为NCT00072995。AM J Clin Nutr 2012；96：1129-36。
Background: TCF7L2 gene variants have been associated with increased risk of type 2 diabetes and higher adiposity. Observational studies and short-term trials have suggested that macronutrients may modify these effects. However, to our knowledge, this has yet to be verified in long-term interventions.Objective: In a long-term intervention setting, we investigated the effects of TCF7L2 polymorphisms rs7903146 and rs12255372 and dietary total fat on changes in body composition and subsequent glycemic control.Design: Data were analyzed for 591 participants in the Preventing Overweight Using Novel Dietary Strategies (Pounds Lost) trial, which is a 2-y weight-loss randomized clinical trial of diets that differed in macronutrient proportions. Adjusted means for changes in body composition at 6 and 24 mo were obtained for gene main effects and interactions with a low-fat diet (20% from energy) compared with a high-fat diet (40% from energy). Interactions with protein and carbohydrate intakes were also tested. Predicted changes in glycemic control from changes in adiposity were determined by genotype and diet type.Results: Significant interactions were observed for rs12255372 TT (risk genotype) and fat intake for changes in BMI, total fat mass, and trunk fat mass (all P/q < 0.05) at 6 mo, with nonsignificant larger decreases for TT carriers on a low-fat diet. No significant associations were observed at 24 mo or for other macronutrients. Changes in body composition for TT carriers predicted reductions in plasma glucose and insulin only on the low-fat diet.Conclusions: Individuals with the TCF7L2 rs12255372 risk genotype may reduce body adiposity by consuming a diet lower in total fat. These reductions may induce better glycemic control for such individuals predisposed to type 2 diabetes. The Pounds Lost trial was registered at clinicaltrials.gov as NCT00072995. Am J Clin Nutr 2012;96:1129-36.