Associations of adiponectin levels with incident impaired glucose metabolism and type 2 diabetes in older men and women - The Hoorn study
Associations of adiponectin levels with incident impaired glucose metabolism and type 2 diabetes in older men and women - The Hoorn study
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DOI：
10.2337/dc06-0952
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发表时间：
2006-11-01
期刊：
影响因子：
16.2
通讯作者：
Dekker, Jacqueline M.
中科院分区：
文献类型：
--
作者：
Snijder, Marieke B.;Heine, Robert J.;Dekker, Jacqueline M.
目的-脂联素是一种脂肪组织来源的蛋白质。低水平与肥胖、胰岛素抵抗和2型糖尿病有关。我们的目的是调查脂联素水平和6.4年的2型糖尿病和糖代谢受损（IGM）的风险之间的前瞻性关联。研究设计和方法-Hoorn研究是一项在50-75岁的白人中进行的队列研究。在基线时测量BMI、腰臀比（WHR）、空腹血糖、2小时血糖、甘油三酯、HDL胆固醇、LDL胆固醇、丙氨酸氨基转移酶、瘦素和脂联素。生活方式（饮酒，吸烟和体力活动）通过问卷调查进行评估。平均随访6.4年后，通过75克口服葡萄糖耐量试验评估葡萄糖耐量。研究分析了1,264名受试者（584名男性和680名女性），他们在基线时没有2型糖尿病。对于事件IGM的分析，239例基线时IGM和/或随访时2型糖尿病的受试者被排除。结果-年龄和生活方式调整的优势比和95%CI比较最高与最低脂联素四分位数为0.52 2型糖尿病男性为0.23-1.18，女性为0.15（0.06-0.39），IGM为0.90（0.51-1.61），女性为0.28（0.16-0.48）。在调整腰臀比和瘦素作为（腹部）肥胖的标志物后，风险仅略有降低。基线空腹和餐后血糖水平校正（潜在的介质）大大减少了这些与2型糖尿病的反向关联（0.79 [0.32-1.91]和0.62 [0.21-1.81]）和IGM（1.20 [0.61-2.35]和0.48 [0.26-0.90]）。结论-高脂联素水平与IGM和2型糖尿病的低风险密切相关，尤其是在女性中。这些结果表明，脂联素参与了肥胖与2型糖尿病的病理生理学联系。
OBJECTIVE - Adiponectin is an adipose tissue-derived protein. Low levels are associated with obesity, insulin resistance, and type 2 diabetes. Our objective was to investigate the prospective association between adiponectin levels and the 6.4-year risk of type 2 diabetes and of impaired glucose metabolism (IGM).RESEARCH DESIGN AND METHODS - The Hoorn Study is a cohort study among Caucasians, aged 50-75 years. BMI, waist-to-hip ratio (WHR), fasting glucose, 2-h glucose, triglycerides, HDL cholesterol, LDL cholesterol, alanine aminotransferase, leptin, and adiponectin were measured at baseline. Lifestyle (alcohol intake, smoking, and physical activity) was assessed by questionnaires. After a mean follow-up of 6.4 years, glucose tolerance was assessed by a 75-g oral glucose tolerance test. Analyses were performed in 1,264 subjects (584 men and 680 women) without type 2 diabetes at baseline. For analyses of incident IGM, 239 subjects with IGM at baseline and/or type 2 diabetes at follow-up were excluded.RESULTS - Age- and lifestyle-adjusted odds ratios and 95% CIs comparing highest with lowest adiponectin quartile were 0.52 (0.23-1.18) in men and 0.15 (0.06-0.39) in women for type 2 diabetes and 0.90 (0.51-1.61) and 0.28 (0.16-0.48) for IGM, respectively. The risks were only slightly reduced after adjustment for WHR and leptin as markers of (abdominal) adiposity. Adjustment for baseline fasting and postload glucose levels (potential mediators) substantially diminished these inverse associations with type 2 diabetes (0.79 [0.32-1.91] and 0.62 [0.21-1.81]) and with IGM (1.20 [0.61-2.35] and 0.48 [0.26-0.90]), respectively.CONCLUSIONS - A high adiponectin level was strongly associated with a lower risk of IGM and type 2 diabetes, particularly in women. These results suggest that adiponectin is involved in the pathophysiology linking obesity to type 2 diabetes.