Response of rabbit Achilles tendon to chronic repetitive loading
Response of rabbit Achilles tendon to chronic repetitive loading
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DOI：
10.3109/03008200109014245
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发表时间：
2001-01-01
影响因子：
2.9
通讯作者：
Herzog, W
中科院分区：
文献类型：
--
作者：
Archambault, JM;Hart, DA;Herzog, W
本研究的目的是评估肌腱对慢性重复性负荷的反应。采用可控肌肉刺激法，以1.25 Hz频率每天2小时，每周3天，连续11周对兔跟腱进行负荷。试验期间肌腱平均峰值力为26 N。加载方案没有改变组织的大体形态，也没有改变其含水量或细胞结构。观察到III型胶原和MMPs mRNA表达增加，但通过肌腱和副腱结构的组织学检查未发现损伤迹象。缺乏可检测的损伤反应表明，肌腱没有受到超过其修复能力的负荷，老化、疾病或压力等机械负荷外的因素可能是产生病理的必要因素。
The objective of this work was to assess the response of tendon to chronic repetitive loading. Controlled muscle stimulation was used to load the rabbit Achilles tendon at a frequency of 1.25 Hz for two hours per day, three days per week for a period of 11 weeks. Average peak tendon force was 26 N during the Protocol. The loading protocol did not modify the gross morphology of the tissue, nor its water content or cellularity. Increases in mRNA expression of collagen Type III and MMPs were observed, but no signs of injury were detected by histologic examination of tendon and paratenon structures. The lack of a detectable injury response suggests that the tendons were not loaded beyond their capacity for repair, Factors additional to mechanical loading such as aging, illness or stress may be necessary to produce pathology.