Measuring change in dry-mouth symptoms over time using the Xerostomia inventory
Measuring change in dry-mouth symptoms over time using the Xerostomia inventory
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DOI：
10.1111/j.1741-2358.2007.00137.x
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发表时间：
2007-03-01
期刊：
影响因子：
2
通讯作者：
Thomson, W. Murray
中科院分区：
文献类型：
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作者：
Thomson, W. Murray
目的：检查口干症量表 (XI) 变化的反应性。背景：XI 是一个 11 项汇总评分量表，其结果是代表慢性口干症严重程度的单个连续量表评分。虽然 XI 已被用作临床研究中的结果衡量标准，但临床上有意义的变化评分的大小尚未确定。 方法：本研究包括对两组口干症症状变化的纵向研究的数据进行二次分析，这两组患者的症状轨迹可能存在很大差异：正常组是无症状的中年和老年人的方便样本，他们对口干的感知在其他方面是稳定的；发病组包括即将接受头颈癌放射治疗的患者（因此预计在基线测量后会出现更严重的口干症）。统计分析检查了横截面结构有效性和内部一致性、重测可靠性以及测量的响应性和纵向结构有效性。那些报告有“一点点”改善的人的平均变化分数被用来确定 XI 的最小重要差异。结果：超过三分之二的发病组成员在随访（2 个月）时报告“经常”或“总是”口干，并且他们的平均 XI 分数也随之增加。重测可靠性是可以接受的。对发生变化的人和观察到稳定的人的个体内部变化的检查表明，只有那些病情恶化的人在随访时的 XI 分数显着更高。反映口干症症状恶化的最小重要差异被确定为 6 个等级点。在基线和 2 个月之间，32 名参与者 (33.7%) 的 XI 评分恶化了最小重要差异（正常组和发病组分别为 7.1% 和 54.7%；p < 0.0001）。结论：XI 的有效性和反应性似乎是可以接受的，XI 评分变化 6 分或更多具有临床意义。
Objective: To examine the responsiveness to change of the Xerostomia Inventory (XI).Background: The XI is an 11-item summated rating scale which results in a single continuous scale score representing the severity of chronic xerostomia. While the XI has been used as an outcome measure in clinical research, the magnitude of a clinically meaningful change score has yet to be determined.Methods: This study comprises a secondary analysis of data front a longitudinal study of changes in xerostomia symptoms in two groups whose symptom trajectories were likely to differ substantially: the normal group was a convenience sample of asymptomatic middle-aged and older individuals with otherwise stable perceptions of mouth dryness; and the onset group comprised patients who were about to undergo radiotherapy for head/neck cancer (and would therefore be expected to develop more severe xerostomia after the baseline measurements). Statistical analyses examined cross-sectional construct validity and internal consistency, test-retest reliability and the measure's responsiveness and longitudinal construct validity. The mean change scores of those for whom 'a little' improvement was reported were used to determine the minimally important difference for the XI.Results: Over two-thirds of the onset group members reported dry mouth 'frequently' or 'always' at follow-up (2 months) and there was a concomitant increase in their mean XI score. Test-retest reliability was acceptable. Examination of within-individual change among those who changed and those for whom stability was observed, showed that only those who worsened had significantly greater XI scores at followup. The minimally important difference to reflect deterioration in xerostomia symptoms was determined to be 6 scale points. Between baseline and 2 months, the XI scores of 32 participants (33.7%) deteriorated by the minimally important difference (7.1% and 54.7% respectively among the normal and onset groups; p < 0.0001).Conclusion: The validity and responsiveness of the XI appear to be acceptable, and a change in XI score of 6 or more points is clinically meaningful.