CONDITIONED PLACE PREFERENCE - AN EVALUATION OF MORPHINES POSITIVE REINFORCING PROPERTIES
CONDITIONED PLACE PREFERENCE - AN EVALUATION OF MORPHINES POSITIVE REINFORCING PROPERTIES
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DOI：
10.1007/bf00432040
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发表时间：
1984-01-01
影响因子：
3.4
通讯作者：
AMIT, Z
中科院分区：
文献类型：
--
作者：
BLANDER, A;HUNT, T;AMIT, Z
位置偏好范式被评估为吗啡的正强化特性的量度。先前的位置偏好研究获得了26- 63%的吗啡位置偏好。为了检验程序上的差异是否可以解释这种分散，本实验研究了当大鼠在盒子的非偏好侧条件化时或当动物被随机分配到条件化侧时，偏好的绝对大小是否存在任何差异。预处理天数延长3个试验日，每个试验日后药物剂量加倍。结果表明，在非偏好侧或随机分配到调节侧的调节动物之间没有显著差异。然而，通过延长调节天数以及遵循所用药物方案，动物显示出比先前研究中观察到的更大程度的偏好。这些研究结果的影响，使用这种范式作为衡量吗啡的积极强化性能进行了讨论。
The place-preference paradigm was evaluated as a measure of morphine''s positive reinforcing properties. Previous place-preference studies obtained a morphine place preference of 26-63%. To examine whether differences in procedure may account for this scatter, the present experiment investigated whether there is any difference in the absolute magnitude of preference when rats are conditioned on their nonpreferred side of the box or when animals are randomly assigned to the side of conditioning. The number of conditioning days was extended with 3 intervening test days, and drug doses were doubled following each test day. The results showed no significant difference between conditioning animals on their nonpreferred side or randomly assigning them to the side of conditioning. However, by extending the number of conditioning days, as well as by following the drug regimen used, the animals showed a greater magnitude of preference than that observed in previous studies. The implications of these findings for the usage of this paradigm as a measure of morphine''s positive reinforcing properties are discussed.