Neo-clerodane diterpenes and phytoecdysteroids from Ajuga decumbens Thunb. and evaluation of their effects on cytotoxic, superoxide anion generation and elastase release in vitro
Neo-clerodane diterpenes and phytoecdysteroids from Ajuga decumbens Thunb. and evaluation of their effects on cytotoxic, superoxide anion generation and elastase release in vitro
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DOI：
10.1016/j.fitote.2018.06.004
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发表时间：
2018-09-01
期刊：
影响因子：
3.4
通讯作者：
Sun, Jian-Bo
中科院分区：
文献类型：
--
作者：
Chen, Hao;Tang, Ben-Qin;Sun, Jian-Bo
从唇形科植物 Ajuga decumbens（唇形科）的全草中分离出五种新化合物，包括四种新氯丹二萜类化合物，名为 ajugacumbins K-N (1-4) 以及一种植物蜕皮甾酮，名为 ajugacetalsterone E (5)。它们的结构是在详细的光谱分析（包括 IR、HRESIMS、CD、1D 和 2D NMR 光谱实验）的基础上阐明的。评估了化合物 1-5 的细胞毒性活性以及对 FMLP/CB 诱导的人中性粒细胞中超氧阴离子生成和弹性蛋白酶释放的影响。
Five novel compounds, including four neoclerodane diterpenoids, named ajugacumbins K-N (1-4) along with a phytoecdysterone, named ajugacetalsterone E (5), were isolated from the whole herbs of Ajuga decumbens (Labiatae). Their structures were elucidated on the basis of detailed spectroscopic analysis including IR, HRESIMS, CD, 1D and 2D NMR spectroscopic experiments. Compounds 1-5 were evaluated for their cytotoxic activities and the effects on superoxide anion generation and elastase release in FMLP/CB-induced human neutrophils.