Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis
Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis
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DOI：
10.1007/s00403-014-1488-0
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发表时间：
2014-12-01
影响因子：
3
通讯作者：
Uguccioni, M.
中科院分区：
文献类型：
--
作者：
Kakeda, M.;Schlapbach, Christoph;Uguccioni, M.
急性泛发性暴露性脓疱病（AGEP）和泛发性脓疱性银屑病（GPP）是一种罕见的全身性脓疱性皮肤病。IL-17 A/F是参与多种嗜酸性炎症性疾病的促炎细胞因子。在这里，我们表明，IL-17 A/F是高度表达的先天性免疫细胞，如中性粒细胞和肥大细胞在AGEP和GPP。
Acute generalized exanthematous pustulosis (AGEP) and generalized pustular psoriasis (GPP) are rare pustular skin disorders with systemic involvement. IL-17A/F is a proinflammatory cytokine involved in various neutrophilic inflammatory disorders. Here we show that IL-17A/F is highly expressed by innate immune cells such as neutrophils and mast cells in both AGEP and GPP.