Protection Efficacy of the Extract of Ginkgo biloba against the Learning and Memory Damage of Rats under Repeated High Sustained +Gz Exposure.
Protection Efficacy of the Extract of Ginkgo biloba against the Learning and Memory Damage of Rats under Repeated High Sustained +Gz Exposure.
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DOI：
10.1155/2016/6320586
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Zhan H
中科院分区：
文献类型：
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作者：
Chen LE;Wu F;Zhao A;Ge H;Zhan H
已知重复高持续正 Gz (+Gz) 暴露会对大鼠大脑产生有害的病理生理影响，表现为正常学习和记忆能力的中断。有趣的是，据报道银杏叶提取物 (EGb) 具有神经保护作用和认知增强作用。在这项研究中，我们有兴趣评估 EGb 对学习和记忆能力的保护作用。采用莫里斯水迷宫测试（MWM）评估认知功能，并考察中枢胆碱能系统关键组成部分的生理状态。我们的动物行为测试表明EGb可以缓解重复高持续+Gz引起的学习和记忆障碍。给大鼠施用 EGb 可以减少重复暴露于+Gz 引起的一些有害生理效应。此外，施用EGb可以增加超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的生物活性，但减少丙二醛（MDA）的产生。综上所述，我们的研究表明EGb可以改善重复高持续+Gz暴露引起的大鼠学习和记忆能力的损伤；其潜在机制似乎与胆碱能系统和抗氧化酶系统的信号调节有关。
Repeated high sustained positive Gz (+Gz) exposures are known for the harmful pathophysiological impact on the brain of rats, which is reflected as the interruption of normal performance of learning and memory. Interestingly, extract of Ginkgo biloba (EGb) has been reported to have neuroprotective effects and cognition-enhancing effects. In this study, we are interested in evaluating the protective effects of EGb toward the learning and memory abilities. Morris Water Maze Test (MWM) was used to evaluate the cognitive function, and the physiological status of the key components in central cholinergic system was also investigated. Our animal behavioral tests indicated that EGb can release the learning and memory impairment caused by repeated high sustained +Gz. Administration of EGb to rats can diminish some of the harmful physiological effects caused by repeated +Gz exposures. Moreover, EGb administration can increase the biological activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) but reduce the production of malondialdehyde (MDA). Taken together, our study showed that EGb can ameliorate the impairment of learning and memory abilities of rats induced by repeated high sustained +Gz exposure; the underlying mechanisms appeared to be related to the signal regulation on the cholinergic system and antioxidant enzymes system.