Myocardin and Kv1 Channels: A Paradigm Shift in Treating Vascular Smooth Muscle Cell-Related Proliferative Disease?
Myocardin and Kv1 Channels: A Paradigm Shift in Treating Vascular Smooth Muscle Cell-Related Proliferative Disease?
复制标题
心肌素和 Kv1 通道：治疗血管平滑肌细胞相关增殖性疾病的范式转变？
DOI：
10.1161/atvbaha.119.313531
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Gutterman,DavidD
中科院分区：
文献类型：
--
作者：
Zhang,DavidX;Gutterman,DavidD
Phenotypic modulation is an important physiological property of vascular smooth muscle cells (VSMCs) that allows transition from the differentiated, contractile phenotype to the proliferative, migratory, and secretory phenotype. 1 This switch of the VSMC phenotype is an essential process of vascular remodeling and occurs during growth and development, as well as in response to vascular injury or disease. Although multiple signaling processes are involved, K+ channels have been implicated as critical players in VSMC proliferation and vascular remodeling. 2 Changes in the expression and function of K+ channels, such as KCa3. 1, Kv3. 4, and Kv1. 3, have been linked with VSMC proliferation in different experimental models. 3–5 In addition, blockade of K+ channels inhibits the proliferation of many cell types, including VSMCs. 6
影响因子：
20.1
作者：
Miguel-Velado, E;Moreno-Domínguez, A;López-López, JR
通讯作者：
López-López, JR