MECHANISMS UNDERLYING SOMATOSENSORY CORTICAL DYNAMICS .2. INVITRO STUDIES
MECHANISMS UNDERLYING SOMATOSENSORY CORTICAL DYNAMICS .2. INVITRO STUDIES
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DOI：
10.1093/cercor/2.2.107
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发表时间：
1992-03-01
期刊：
影响因子：
3.7
通讯作者：
TOMMERDAHL, M
中科院分区：
文献类型：
--
作者：
LEE, CJ;WHITSEL, BL;TOMMERDAHL, M
使用诱发电位和代谢映射 [2-脱氧葡萄糖 (2DG)] 方法来映射感觉运动皮质切片对重复的单点传入驱动的响应。在重复 3-5 Hz 刺激期间，诱发电位会发生系统性变化（增加或减少）。这些类似于前一篇配套文章的体内研究中观察到的 SI 神经元反应的变化；它们发生迅速，在 1 分钟内恢复，并且在刺激参数保持不变的情况下是可重现的。重复刺激的地点、时间和强度会影响在给定皮质位点观察到的反应变化的幅度和形式。对相同重复刺激表现出不同反应修改的神经元群体在切片中非随机分布：占据柱状聚集体的神经元在重复刺激期间经历共同的反应改变（增加或减少），并根据其动态行为区分相邻聚集体的清晰边界。切片中刺激诱发的 2DG 摄取的分布是“柱状”的，2DG 柱的尺寸对应于用神经生理学方法绘制的尺寸。总之，这些发现支持这样的概念，即重复刺激导致体感皮层的内在网络动态地修改网络对外在兴奋性驱动的反应，从而增强对邻近皮层柱的外在兴奋性驱动模式的局部差异。
The response of the sensorimotor cortical slice to repetitive, single-site afferent drive is mapped using both evoked potential and metabolic mapping [2-deoxyglucose (2DG)] methods. Systematic changes (increases or decreases) in the evoked potential occur during repetitive 3-5 Hz stimulation. These resemble the changes in SI neuron response observed in the in vivo studies of the preceding companion article; they occur rapidly, recover within 1 min and are reproducible if stimulus parameters remain unchanged. Place, timing, and intensity of repetitive stimulation influence the amplitude and form of the response alterations observed at a given cortical locus. The neuron populations that exhibit different response modifications to the same repetitive stimulus are distributed nonrandomly in the slice: neurons occupying column-shaped aggregates undergo a common response alteration (either an increase or decrease) during repetitive stimulation, with sharp boundaries separating neighboring aggregates distinguishable on the basis of their dynamic behaviors. The distribution of stimulus-evoked 2DG uptake in the slice is "columnar," the dimensions of the 2DG columns corresponding to those mapped with neurophysiological methods.Taken together, the findings support the concept that repetitive stimulation causes the intrinsic network of somatosensory cortex to modify dynamically the network's response to extrinsic excitatory drive so that the local differences in the pattern of extrinsic excitatory drive to neighboring cortical columns are enhanced.