Increased Group 2 Innate Lymphoid Cells Are Correlated with Eosinophilic Granulocytes in Patients with Allergic Airway Inflammation
Increased Group 2 Innate Lymphoid Cells Are Correlated with Eosinophilic Granulocytes in Patients with Allergic Airway Inflammation
复制标题
过敏性气道炎症患者中第 2 组先天淋巴细胞增多与嗜酸性粒细胞相关
DOI：
10.1159/000488050
复制
发表时间：
2018
影响因子：
2.8
通讯作者：
Fu Qing Ling
中科院分区：
文献类型：
--
作者：
Yu Qiu Ning;Tan Wei Ping;Fan Xing Liang;Guo Yu Biao;Qin Zi Li;Li Cheng Lin;Chen Dong;Lin Zhi Bin;Wen Weiping;Fu Qing Ling
辅助性T细胞2（Th2）型反应被认为是变应性气道疾病（包括哮喘和变应性鼻炎（AR））的本质。然而，最近的研究表明，过敏性气道炎症也依赖于先天免疫，并与第2组先天淋巴样细胞（ILC2）密切相关。本研究评估了哮喘受试者、哮喘和AR患者以及健康个体的ILC2水平，关于如何调查临床数据与ILC2水平之间的关系。结果发现，与健康受试者相比，哮喘患者和哮喘伴AR患者具有更高的ILC2水平。哮喘和AR患者ILC2与嗜酸性粒细胞百分比呈正相关，但与肺功能无关。轻度哮喘患者ILC2水平高于重度哮喘患者。本研究为变应性气道炎症的发病机制提供了新的解释，可能为变应性气道疾病的诊断和评估提供新的方向。
The T helper 2 (Th2)-type response was considered the hypostasis of allergic airway diseases, including asthma and allergic rhinitis (AR). However, more recent studies have suggested that allergic airway inflammation also depends on innate immunity and is closely related to group 2 innate lymphoid cells (ILC2s). This study evaluated the ILC2 levels of asthma subjects, patients with asthma and AR, and healthy individuals, regarding how to investigate the relationship between clinical data and ILC2 levels. It was found that asthma patients and asthma with AR patients had higher ILC2 levels compared to healthy subjects. ILC2s were positively correlated with the percentage of eosinophils in patients with asthma and AR, but not with pulmonary function. ILC2 levels were higher in mild asthma subjects than in patients with severe asthma. This study provides a new interpretation of the pathogenesis of allergic airway inflammation and may provide a new direction for the diagnosis and assessment of allergic airway diseases.