Gut Microbiota in Psychiatric Disorders: A Systematic Review.
Gut Microbiota in Psychiatric Disorders: A Systematic Review.
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DOI：
10.1097/psy.0000000000000959
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发表时间：
2021-09-01
影响因子：
3.3
通讯作者：
Djurfeldt D
中科院分区：
文献类型：
--
作者：
Chen LL;Abbaspour A;Mkoma GF;Bulik CM;Rück C;Djurfeldt D
补充数字内容可在文本中找到。这项系统性综述旨在全面总结遵循PRISMA指南的精神疾病肠道微生物群研究。使用涉及肠道微生物群和精神疾病的关键词对数据库进行文献检索。对截至2020年2月13日的人类参与者的英文文献进行了审查。使用微生物群研究的改良Newcastle-Ottawa量表评估偏倚风险。识别出的4231项研究中有69项符合提取的入选标准。在大多数研究中，患有精神疾病的个体和健康对照之间的肠道微生物群组成不同;然而，在分类学特征中观察到有限的一致性。在属水平上，最重复的发现是精神疾病患者中双歧杆菌的丰度较高，罗斯拜瑞氏菌属和粪杆菌属的丰度较低。产生短链脂肪酸的肠道细菌，如罗斯拜瑞氏菌属和粪杆菌属，在精神疾病患者中可能不那么丰富，而双歧杆菌属等肠道细菌可能比健康对照组更丰富。然而，大多数纳入的研究受到方法学缺陷的阻碍，包括样本量小，诊断不明确，未能解决混杂因素，以及生物信息学处理不充分，这可能导致结果不一致。根据我们的研究结果，我们提出了建议，以提高未来精神病学微生物群研究的质量和可比性。
Supplemental digital content is available in the text. This systematic review sought to comprehensively summarize gut microbiota research in psychiatric disorders following PRISMA guidelines. Literature searches were performed on databases using keywords involving gut microbiota and psychiatric disorders. Articles in English with human participants up until February 13, 2020, were reviewed. Risk of bias was assessed using a modified Newcastle-Ottawa Scale for microbiota studies. Sixty-nine of 4231 identified studies met the inclusion criteria for extraction. In most studies, gut microbiota composition differed between individuals with psychiatric disorders and healthy controls; however, limited consistency was observed in the taxonomic profiles. At the genus level, the most replicated findings were higher abundance of Bifidobacterium and lower abundance of Roseburia and Faecalibacterium among patients with psychiatric disorders. Gut bacteria that produce short-chain fatty acids, such as Roseburia and Faecalibacterium, could be less abundant in patients with psychiatric disorders, whereas commensal genera, for example, Bifidobacterium, might be more abundant compared with healthy controls. However, most included studies were hampered by methodological shortcomings including small sample size, unclear diagnostics, failure to address confounding factors, and inadequate bioinformatic processing, which might contribute to inconsistent results. Based on our findings, we provide recommendations to improve quality and comparability of future microbiota studies in psychiatry.