Hypoglycemia increases serum interleukin-6 levels in healthy men and women
Hypoglycemia increases serum interleukin-6 levels in healthy men and women
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DOI：
10.2337/dc07-2243
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发表时间：
2008-06-01
期刊：
影响因子：
16.2
通讯作者：
Adler, Gail K.
中科院分区：
文献类型：
--
作者：
Dotson, Sarah;Freeman, Roy;Adler, Gail K.
目的-炎症可能在危重病的发病机制和预后中起主要作用.高血压增加炎症细胞因子白细胞介素-6（IL-6）的水平，并与发病率和死亡率的风险增加有关。由于低血糖也与不良结局相关，我们检验了低血糖增加IL-6的假设。研究设计和方法-17名健康男性和女性参加了低血糖和正常血糖-高胰岛素钳夹研究（目标血糖水平分别为2.7和5.0 mmol/l），间隔1-3个月。IL-6、ACTH和皮质醇在基线和开始胰岛素输注后45、75、105和135分钟进行测量。结果- IL-6、ACTH和皮质醇水平在低血糖时显著升高（P < 0.0001），但在正常血糖时无显著升高。IL-6从基线时的平均值± SEM 1.0 ± 0.2 pg/ml增加到低血糖135分钟后的2.6 ± 0.2 pg/ml，而IL-6水平在正常人中无变化。
OBJECTIVE - Inflammation may have a major role in the pathogenesis and prognosis of critical illness. Hyperglycemia increases levels of the inflammatory cytokine interleukin-6 (IL-6) and is associated with increased risks of morbidity and mortality. Because hypoglycemia is also associated with adverse outcomes, we tested the hypothesis that hypoglycemia increases IL-6.RESEARCH DESIGN AND METHODS - Seventeen healthy men and women participated in hypoglycemic and euglycemic-hyperinsulinemic clamp studies (target blood glucose levels 2.7 and 5.0 mmol/l, respectively), separated by 1-3 months. IL-6, ACTH, and cortisol were measured at baseline and at 45, 75, 105, and 135 min after initiation of the insulin infusion.RESULTS - IL-6, ACTH, and cortisol levels increased significantly (P < 0.0001) during hypoglycemia but not euglycemia. IL-6 increased from mean +/- SEM 1.0 +/- 0.2 pg/ml at baseline to 2.6 +/- 0.2 pg/ml after 135 min of hypoglycemia, whereas IL-6 levels were unchanged during euglycemia.CONCLUSIONS - Hypoglycemia increases IL-6 levels in healthy individuals.