Computer modeling of prototypic and aberrant nucleocapsids of varicella-zoster virus.
Computer modeling of prototypic and aberrant nucleocapsids of varicella-zoster virus.
复制标题
水痘带状疱疹病毒原型和异常核衣壳的计算机建模。
DOI：
10.1006/viro.1995.0041
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Beck,S
中科院分区：
文献类型：
--
作者：
Grose,C;Harson,R;Beck,S
322 GROSE、HARSON和BECK磁芯如图3所示。我们认识到Booy等人的观察。（1991）包装的DNA可以径向延伸到HSV衣壳壳的内表面。然而，为了建模的目的，我们需要为DNA类核指定特定的大小;数据并不意味着核心周围有任何蛋白质壳（Schrag et al.，1989年）。异常VZV核衣壳的三维模型如图4所示。原型模型符合HSV文献中C粒子的定义（吉布森和Roizman，1972），而具有异常核的VZV粒子在HSV文献中没有相应的字母形式。尽管我们还不知道后一种粒子是否含有病毒DNA，但为了统一起见，我们在本文中称这种粒子为核衣壳。少数核心不含物质的VZV颗粒可能对应于HSV文献中的A衣壳;这些形式未建模。
322 GROSE, HARSON, AND BECK core is shown in Fig. 3. We recognize the observation by Booy et al.(1991) that packaged DNA may extend radially to the inner surface of the HSV capsid shell. Yet, for purposes of modeling, we needed to assign a specific size to the DNA nucleoid; the data do not imply any protein shell around the core (Schrag et al., 1989). The 3-D model of the aberrant VZV nucleocapsid is illustrated in Fig. 4. The prototypic model fits the definition of a C particle in the HSV literature (Gibson and Roizman, 1972), while the VZV particle with an aberrant core has no corresponding lettered form in the HSV literature. Even though we do not yet know whether the latter particle contains viral DNA, for uniformity we have called the particle a nucleocapsid within this text. A small number of VZV particles which contain no material in their core probably correspond to the A capsid in the HSV literature; these forms were not modeled.