[The effect of plasmapheresis with high-dose intravenous methylprednisolone therapy on cytokine synthesis of peripheral blood monocyte from patients with myasthenia gravis].
[The effect of plasmapheresis with high-dose intravenous methylprednisolone therapy on cytokine synthesis of peripheral blood monocyte from patients with myasthenia gravis].
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大剂量静脉注射甲泼尼龙血浆置换对重症肌无力患者外周血单核细胞细胞因子合成的影响
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
Y. Ngane
中科院分区：
文献类型：
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作者：
R. Matsubara;K. Utsugisawa;Y. Ngane
为探讨血浆置换(PP)对重症肌无力(MG)患者外周血单核细胞(PBM)细胞因子合成的影响，对7例重症肌无力(MG)患者(PP组1例，PP+大剂量甲基强的松龙冲击疗法(PU组)6例)外周血单核细胞(PBM)产生IL-1β和IL-2进行了研究。PP后即刻，PBM IL-2产生减少，PBM IL-1β产生增加。在只接受PP的患者中，PBM IL-2的产生再次增加，PBM IL-1β的产生在第二天一直保持在高值。但在接受PP+PU治疗的6名患者中，与仅接受PP治疗的患者相比，PBM IL-2的产生在第二天保持显著(p<；0.01)。在反复接受PP+PU治疗的4例患者中，随着PBM IL-2产生的逐渐减少，MG的严重程度有所改善。提示PP对MG患者PBM IL-2的产生有下调作用，对PBM IL-1β的产生有上调作用，PP+PU联合PP可抑制MG患者PBM IL-1β的合成。
We studied interleukin-1 beta (IL-1 beta) and interleukin-2 (IL-2) production by peripheral blood monocyte (PBM) from 7 patients with myasthenia gravis (MG) receiving plasmapheresis (PP) (PP therapy only, one patient; PP+high dose intravenous methylprednisolone therapy (pulse therapy: pu therapy), 6 patients) to evaluate the effects of PP therapy on cytokine synthesis of PBM from MG patients. Immediately after PP, PBM IL-2 production decreased and PBM IL-1 beta production increased. In a patient receiving PP only, PBM IL-2 production increased again and PBM IL-1 beta production maintained the high value through the next day. But in 6 patients receiving PP+pu therapy, PBM IL-2 production maintained significantly (p < 0.01) through the next day compared with a patient receiving PP only. In four patients receiving repeated PP+pu therapy, as PBM IL-2 production gradually reduced, the severity of MG improved. These findings suggest that PP in MG had the effects of down-regulation of PBM IL-2 production and up-regulation of PBM IL-1 beta production, and that PP+pu therapy combined with PP suppresses the enhanced PBM IL-1 beta synthesis in MG patients.