Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs
Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs
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DOI：
10.1096/fj.03-0996fje
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发表时间：
2004-05-01
期刊：
影响因子：
4.8
通讯作者：
Calise, F
中科院分区：
文献类型：
--
作者：
Lavitrano, M;Smolenski, RT;Calise, F
缺血-再灌注损伤是心脏手术中的一个临床问题，涉及三磷酸腺苷（ATP）生成的恶化和对心脏的损伤。我们研究了一氧化碳（CO）预处理，证明有价值的啮齿动物，但以前没有在大型动物中测试，其对猪心脏进行心肺转流心脏停搏。CO处理的猪的心脏表现出显着更高的ATP和磷酸肌酸水平，间质水肿，心肌细胞凋亡和需要更少的除颤旁路后。我们的结论是，治疗与CO改善能源状况，防止水肿形成和细胞凋亡，并促进复苏，在临床相关模型的心肺转流手术。
Ischemia-reperfusion injury, a clinical problem during cardiac surgery, involves worsened adenosine trisphosphate (ATP) generation and damage to the heart. We studied carbon monoxide ( CO) pretreatment, proven valuable in rodents but not previously tested in large animals, for its effects on pig hearts subjected to cardiopulmonary bypass with cardioplegic arrest. Hearts of CO-treated pigs showed significantly higher ATP and phosphocreatine levels, less interstitial edema, and apoptosis of cardiomyocytes and required fewer defibrillations after bypass. We conclude that treatment with CO improves the energy status, prevents edema formation and apoptosis, and facilitates recovery in a clinically relevant model of cardiopulmonary bypass surgery.