Hippocampal volume changes in healthy subjects at risk of unipolar depression
Hippocampal volume changes in healthy subjects at risk of unipolar depression
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DOI：
10.1016/j.jpsychires.2009.12.009
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发表时间：
2010-07-01
影响因子：
4.8
通讯作者：
Kessing, Lars Vedel
中科院分区：
文献类型：
--
作者：
Baare, William F. C.;Vinberg, Maj;Kessing, Lars Vedel
单相抑郁在一定程度上可遗传。目前尚不清楚与单相抑郁相关的结构性大脑变化是否存在于有这种疾病风险的健康人身上。在这里，我们调查了单相抑郁的遗传倾向是否与大脑结构变化有关。先验地，海马体体积减小是假设的。采用高风险研究设计，对59名患有单相抑郁症同卵双胞胎的健康高风险受试者和53名没有严重精神障碍一级家族史的健康低风险受试者进行了磁共振脑扫描。高风险双胞胎的海马体体积比低风险双胞胎小(p<；0.04)。这一发现在DZ双胞胎中最为明显。在探索性体素全脑分析中，两组在整体脑组织体积或局部组织体积评估上没有差异。总而言之，海马体体积减小可能预示着抑郁症的发生，因此可能预示着未来疾病的发生。需要进一步的研究来阐明(共同的)环境和遗传因素的作用。(C)2009爱思唯尔有限公司。保留所有权利。
Unipolar depression is moderately heritable. It is unclear whether structural brain changes associated with unipolar depression are present in healthy persons at risk of the disorder. Here we investigated whether a genetic predisposition to unipolar depression is associated with structural brain changes. A priori, hippocampal volume reductions were hypothesized. Using a high-risk study design, magnetic resonance imaging brain scans were obtained from 59 healthy high-risk subjects having a co-twin with unipolar depression, and 53 healthy low-risk subjects without a first-degree family history of major psychiatric disorder. High-risk twins had smaller hippocampal volumes than low-risk twins (p < 0.04). The finding was most pronounced in DZ twins. Groups did not differ on global brain tissue volumes or regional tissue volumes assessed in exploratory voxel-wise whole cerebrum analyses. In conclusion, hippocampal volume reduction may index a predisposition to develop depression and thus may be predictive of future onset of the disorder. Further studies are needed to elucidate the role of (shared) environmental and genetic factors. (C) 2009 Elsevier Ltd. All rights reserved.