Genomic structure of human transcobalamin II: comparison to human intrinsic factor and transcobalamin I.
Genomic structure of human transcobalamin II: comparison to human intrinsic factor and transcobalamin I.
复制标题
人转钴胺素 II 的基因组结构：与人内因子和转钴胺素 I 的比较。
DOI：
10.1006/bbrc.1995.1402
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Seetharam,B
中科院分区：
文献类型：
--
作者：
Li,N;Seetharam,S;Seetharam,B
Human transcobalamin II (TC II) gene was isolated and partially sequenced. The gene is composed of nine exons and eight introns spanning ∼20 kb. Multiple potential transcription start sites were revealed by primer extension analysis. The 5′-flanking region of the gene contained no TATA-like motif, but a binding motif for HIP1, which is suggested to be important in the transcription of TATA-less housekeeping genes, was identified in a region very close to the initiator methionine codon. In addition, potential binding sites for a variety of transcription factors such as SP1, AP2, CF1, NF-IL6, Ets-l, Myb and E2A were also observed. Comparison of the genomic structure of TC II to other Cbl-binding proteins, human gastric intrinsic factor (IF) and transcobalamin I (TC I) revealed similar intron-exon organizations with respect to the number, position and size of exons. These results suggest that TC II, TC I and IF genes have originated by gene duplications of an ancestral gene and TC II, unlike the other two Cbl-binding proteins, is the product of a "housekeeping" gene.
