Use of ramelteon for the treatment of secondary REM sleep behavior disorder.
Use of ramelteon for the treatment of secondary REM sleep behavior disorder.
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DOI：
10.2169/internalmedicine.52.9179
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发表时间：
2013
影响因子：
1.2
通讯作者：
T. Nomura;Shinya Kawase;Yasuhiro Watanabe;K. Nakashima
中科院分区：
文献类型：
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作者：
T. Nomura;Shinya Kawase;Yasuhiro Watanabe;K. Nakashima
我们使用雷美替恩治疗2例继发性REM睡眠行为障碍（RBD）并发症沿着神经退行性疾病（包括多系统萎缩和帕金森病）的患者。这两名患者不仅改善了他们的临床RBD症状，而且还表现出REM睡眠的比例下降而无张力（两名患者从8.5%降至3.5%和从10.9%降至3.9%）。虽然氯硝西泮是治疗RBD的标准一线疗法，但对于因无效或不良反应而不能服用氯硝西泮的RBD患者，雷美替酮可能是一种有效的治疗替代方案。
We used ramelteon to treat two patients with secondary REM sleep behavior disorder (RBD) complications along with neurodegenerative diseases including multiple system atrophy and Parkinson's disease. These two patients not only improved in terms of their clinical RBD symptoms but also exhibited a decrease in the proportion of REM sleep without atonia (from 8.5% to 3.5% and from 10.9% to 3.9% in the two patients). Although clonazepam is the standard first-line therapy for the treatment of RBD, ramelteon might be an effective treatment alternative in patients with RBD who cannot take clonazepam due to either ineffectiveness or adverse effects.