Antibacterial properties of Cu-doped TiO2 prepared by chemical and heat treatment of Ti metal
Antibacterial properties of Cu-doped TiO2 prepared by chemical and heat treatment of Ti metal
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DOI：
10.1080/21870764.2021.1979287
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发表时间：
2021-10
影响因子：
2.3
通讯作者：
Kanae Suzuki;T. Yokoi;Misato Iwatsu;Maiko Furuya;Kotone Yokota;T. Mokudai;H. Kanetaka;M. Kawashita
中科院分区：
文献类型：
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作者：
Kanae Suzuki;T. Yokoi;Misato Iwatsu;Maiko Furuya;Kotone Yokota;T. Mokudai;H. Kanetaka;M. Kawashita
摘要 在这项研究中，我们提出了通过对钛 (Ti) 金属进行碱性和热处理制备的铜掺杂 TiO2，用于牙科应用，因为它通过释放铜离子和可见光响应光催化而产生骨粘合和抗菌特性。我们成功地在Ti芯片表面制备了Cu含量为7 at.%的Cu掺杂TiO2。使用模拟体液评估Cu掺杂TiO2的磷灰石形成能力，发现发生了磷灰石形成。因此，我们得出结论，Cu 掺杂的 TiO2 具有骨粘合性能。 Cu掺杂TiO2在可见光照射下对大肠杆菌的抗菌性能高于未掺杂TiO2。抗菌效果的增强主要是由于Cu掺杂TiO2的可见光响应光催化作用所致。我们证实，Cu掺杂TiO2的可见光响应光催化作用产生的活性氧是氢氧根离子（OH−）和空穴（h+）反应形成的羟基自由基。我们的研究结果有助于开发新型生物活性二氧化钛基涂料和通过铜掺杂具有抗菌性能的散装材料。
ABSTRACT In this study, we proposed Cu-doped TiO2, prepared by the alkaline and heat treatment of titanium (Ti) metal, for use in dental applications because of its bone-bonding and antibacterial properties generated by the release of Cu ions and visible-light-responsive photocatalysis. We successfully prepared Cu-doped TiO2 on a Ti chip surface with a Cu content of 7 at.%. The apatite-forming ability of the Cu-doped TiO2 was evaluated using a simulated body fluid and it was found that apatite formation occurred. Hence, we concluded that Cu-doped TiO2 exhibits bone-bonding properties. The antibacterial properties of Cu-doped TiO2 for Escherichia coli were higher than those of non-doped TiO2 under visible light irradiation. The enhanced antibacterial effect was mainly caused by the visible-light-responsive photocatalysis of Cu-doped TiO2. We confirmed that the reactive oxygen species generated by the visible-light-responsive photocatalysis of Cu-doped TiO2 were hydroxyl radicals formed by the reaction of hydroxide ions (OH−) and holes (h+). Our findings are useful for the development of novel bioactive TiO2-based coatings and bulk materials with antibacterial properties by Cu doping.