Aminoglycoside-associated nephrotoxicity in the elderly
Aminoglycoside-associated nephrotoxicity in the elderly
复制标题
DOI：
10.1177/106002800303700203
复制
发表时间：
2003-02-01
影响因子：
2.9
通讯作者：
Cowan, RI
中科院分区：
文献类型：
--
作者：
Baciewicz, AM;Sokos, DR;Cowan, RI
目的：为了确定是否有一个增加的发病率肾毒性老年患者（大于或等于65岁）规定单剂量（SD）与多剂量（MD）氨基糖苷类药物，以及氨基糖苷类药物诱导的肾毒性是否与治疗时间和其他风险factors.Methods：一个前瞻性的，观察性审计在大学教学医院进行。根据给药方案使用医生处方对受试者进行分层：MD（n=60）或SD（n=26）。肾毒性被定义为持续超过2 day.Results：86例患者的血清肌酐水平增加0.5 mg/dL; 9.3%的肾毒性，其中62.5%接受SD治疗。治疗方案之间的肾毒性发生率无差异（p=0.051）。发生肾毒性的患者的治疗时间延长（平均值+/-SD 6.1+/-6.2 vs. 3.7+/-2.8 d; p=0.044）。此外，发生肾毒性的患者住院时间延长（20.3+/-16.1 vs. 8.4+/-5.4 d; p
Objective: To determine whether there was an increased incidence of nephrotoxicity in elderly patients (greater than or equal to65 y) prescribed single-dose (SD) versus multiple-dose (MD) aminoglycosides and whether aminoglycoside-induced nephrotoxicity was associated with length of therapy and other risk factors.Methods: A prospective, observational audit at a university teaching hospital was conducted. Physician prescribing was used to stratify subjects according to dosing regimen: MD (n=60) or SD (n=26). Nephrotoxicity was defined as an increase in the serum creatinine level of 0.5 mg/dL sustained over 2 days.Results: Eighty-six patients were included; 9.3% developed nephrotoxicity, of whom 62.5% received SD therapy. The incidence of nephrotoxicity did not differ between regimens (p=0.051). There was an increased length of therapy in those who developed nephrotoxicity (mean+/-SD 6.1+/-6.2 vs. 3.7+/-2.8 d; p=0.044). Additionally, patients who developed nephrotoxicity had an increased length of hospitalization (20.3+/-16.1 vs. 8.4+/-5.4 d; p