A Movement Monitor Based on Magneto-Inertial Sensors for Non-Ambulant Patients with Duchenne Muscular Dystrophy: A Pilot Study in Controlled Environment.
A Movement Monitor Based on Magneto-Inertial Sensors for Non-Ambulant Patients with Duchenne Muscular Dystrophy: A Pilot Study in Controlled Environment.
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DOI：
10.1371/journal.pone.0156696
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Servais L
中科院分区：
文献类型：
--
作者：
Le Moing AG;Seferian AM;Moraux A;Annoussamy M;Dorveaux E;Gasnier E;Hogrel JY;Voit T;Vissière D;Servais L
对于无法行走的神经肌肉疾病患者，上肢肌肉力量和活动度的测量是一项重大挑战。ActiMyo®是一种创新设备，使用磁惯性传感器记录角速度和线加速度，可在家庭环境中长时间使用。该设备旨在确保长期稳定性和良好的信噪比，即使是非常微弱的运动。为了确定相关和相关的临床变量，有可能用作临床试验中的结局指标或指导治疗决策，我们在非走动性神经肌肉患者中进行了一项初步研究。我们在这里报告了在临床环境中收集的7名杜氏肌营养不良症（DMD）患者（平均年龄18.5 ± 5.5岁）的数据。在执行经确认的任务（MoviPlate、Box and Block测试和Minnesota测试）和模拟日常生活的任务期间，对患者佩戴器械进行评估。在所有测试过程中，ActiMyo®传感器都被放置在手腕上。设计用于该设备的软件计算了几个变量，以定性和定量非走动受试者的肌肉活动。研究了代表上肢活动的四个变量：旋转速率、整体加速度中垂直分量的比率、手抬高速率和上肢功率的估计。分析了临床数据和体力活动与ActiMyo®运动参数之间的相关性。旋转率的平均值和上升率的平均值似乎是有希望的，因为这些变量具有最好的可靠性分数和与任务分数的相关性。即使在布鲁克功能评分为6的患者中也可以计算参数。所选变量是Duchenne肌营养不良症非卧床患者的良好候选指标，目前正在家庭环境中探索ActiMyo®的使用。试用注册：ClinicalTrials.gov NCT 01611597
Measurement of muscle strength and activity of upper limbs of non-ambulant patients with neuromuscular diseases is a major challenge. ActiMyo® is an innovative device that uses magneto-inertial sensors to record angular velocities and linear accelerations that can be used over long periods of time in the home environment. The device was designed to insure long-term stability and good signal to noise ratio, even for very weak movements. In order to determine relevant and pertinent clinical variables with potential for use as outcome measures in clinical trials or to guide therapy decisions, we performed a pilot study in non-ambulant neuromuscular patients. We report here data from seven Duchenne Muscular Dystrophy (DMD) patients (mean age 18.5 ± 5.5 years) collected in a clinical setting. Patients were assessed while wearing the device during performance of validated tasks (MoviPlate, Box and Block test and Minnesota test) and tasks mimicking daily living. The ActiMyo® sensors were placed on the wrists during all the tests. Software designed for use with the device computed several variables to qualify and quantify muscular activity in the non-ambulant subjects. Four variables representative of upper limb activity were studied: the rotation rate, the ratio of the vertical component in the overall acceleration, the hand elevation rate, and an estimate of the power of the upper limb. The correlations between clinical data and physical activity and the ActiMyo® movement parameters were analyzed. The mean of the rotation rate and mean of the elevation rate appeared promising since these variables had the best reliability scores and correlations with task scores. Parameters could be computed even in a patient with a Brooke functional score of 6. The variables chosen are good candidates as potential outcome measures in non-ambulant patients with Duchenne Muscular Dystrophy and use of the ActiMyo® is currently being explored in home environment. Trial Registration: ClinicalTrials.gov NCT01611597