Functional changes in inner retinal neurons in animal models of photoreceptor degeneration.

Functional changes in inner retinal neurons in animal models of photoreceptor degeneration.
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光感受器变性动物模型中视网膜内神经元的功能变化。

DOI:
10.1007/978-1-4419-1399-9_60
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发表时间:
2010
影响因子:
--
通讯作者:
Taylor,WRowland
Taylor,WRowland
中科院分区:
医学4区
文献类型:
--
作者:
Puthussery,Theresa;Taylor,WRowland

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Retinitis Pigmentosa (RP) refers to a heterogeneous group of inherited disorders that result in the death of rod and cone photoreceptors. There is now abundant evidence to suggest that inner retinal neurons, particularly the bipolar and horizontal cells, undergo significant morphological changes and changes in neurotransmitter receptor expression in response to photoreceptor degeneration. Some of these alterations could impact the choice and success of intervention strategies for these conditions, and it is therefore necessary to understand the timing and nature of any functional deficits resulting from degenerative changes. This paper will review the evidence for functional alterations in the inner retina in animal models of (RP), with particular emphasis on the bipolar and ganglion cells.
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