Lifetime alcohol intake and risk of rectal cancer in western New York.
Lifetime alcohol intake and risk of rectal cancer in western New York.
复制标题
纽约州西部的终生酒精摄入量和直肠癌风险。
DOI：
10.1080/01635589009514050
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Wilkinson,G
中科院分区：
文献类型：
--
作者：
Freudenheim,JL;Graham,S;Marshall,JR;Haughey,BP;Wilkinson,G
研究人员测量了 1978 年至 1986 年间纽约州西部 277 名男性和 145 名经病理证实患有单发直肠原发性直肠癌的男性和烈性酒的终生摄入量。还采访了年龄、性别和社区相匹配的对照组。啤酒和总酒精的摄入量与直肠癌风险呈正相关。大多数超额风险发生在最酗酒者身上。男性第四个四分位数摄入总酒精的比值比为 1.80 (95% CI, 1.12, 2.89)，啤酒的比值比为 1.86 (1.13, 3.06)。没有发现与葡萄酒或烈性酒的摄入有关。该人群中女性的饮酒量要少得多；趋势相似，但幅度不如男性。饮食风险因素的调整并没有明显改变风险估计。一生中大量摄入啤酒和总酒精与直肠癌风险增加相关，并且这与社会经济状况或饮食无关。
The lifetime intake of total alcohol, beer, wine, and hard liquor was measured for 277 males and 145 females with pathologically confirmed, first, single, primary cancers of the rectum in western New York from 1978 to 1986. Controls who were age, sex, and neighborhood matched were also interviewed. Intake of beer and total alcohol was positively associated with rectal cancer risk. Most of the excess risk was found for the heaviest drinkers. Odds ratios for fourth quartile intakes for males were 1.80 (95% CI, 1.12, 2.89) for total alcohol and 1.86 (1.13, 3.06) for beer. No association was found with wine or hard liquor intake. Females drank considerably less in this population; trends were similar although not of as great magnitude as those for males. Adjustment for dietary risk factors did not change risk estimates appreciably. A high lifetime intake of beer and total alcohol was associated with an increased risk of rectal cancer, and this was independent of either socioeconomic status or diet.