Risk factors for breast cancer: relevance to screening.
Risk factors for breast cancer: relevance to screening.
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乳腺癌的危险因素：与筛查的相关性。
DOI：
10.1136/jech.37.2.127
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发表时间：
1983
影响因子：
6.3
通讯作者：
R. Elton
中科院分区：
文献类型：
--
作者：
S. Duffy;M. Roberts;R. Elton
在一项关于40至60岁妇女乳腺癌危险因素的研究中，从诊断诊所确定的236例病例和参加筛查诊所的2962例无乳腺异常的对照中获得信息。对数据的统计分析使用了另外167名参加过两个诊所的妇女的信息，以纠正问卷调查中可能存在的诊所之间的偏差。在4个5岁年龄组中估计了相对风险，发现55岁以下曾接受过乳腺活检的妇女和50-55岁绝经前或有乳腺癌家族史的妇女有显著的额外风险。没有发现与婚姻状况、首次怀孕年龄、母乳喂养或使用激素药物相关的重大风险。它的结论是，流行病学信息是没有什么价值，在确定高风险群体的筛查计划，在这个年龄范围内。
In a study of risk factors for breast cancer in women aged between 40 and 60 information was obtained from 236 cases identified at a diagnostic clinic and 2962 controls with no breast abnormality who attended a screening clinic. Statistical analysis of the data used information on a further 167 women who had attended both clinics to correct for possible between clinic bias in questionnaire responses. Relative risk was estimated in four 5 year age groups, and a significant excess risk was found for women under 55 who had undergone previous breast biopsy and for women aged 50-55 who were premenopausal or who had a family history of breast cancer. No significant risk was found to be associated with marital status, age at first pregnancy, breast feeding, or use of hormonal drugs. It is concluded that epidemiological information is of little value in identifying high risk groups for a screening programme in this age range.