The Neural Correlates of Emotional Lability in Children with Autism Spectrum Disorder
The Neural Correlates of Emotional Lability in Children with Autism Spectrum Disorder
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DOI：
10.1089/brain.2016.0472
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发表时间：
2017-06-01
影响因子：
3.4
通讯作者：
Di Martino, Adriana
中科院分区：
文献类型：
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作者：
Bennett, Randi H.;Somandepalli, Krishna;Di Martino, Adriana
自闭症谱系障碍(ASD)在临床和生理病理表现上都具有特殊的异质性。临床变异性适用于ASD特有的症状和频繁的共病精神病理，如情绪不稳定(EL)。到目前为止，EL和ASD并存的生理病理基础尚不清楚。作为第一步，我们使用静息状态功能磁共振成像(R-fMRI)检查了ASD内EL及其神经元相关性的个体间变异性。我们分析了58名被诊断为ASD的儿童(5-12岁)的R-fMRI数据与Conners的父母评定量表EL指数的关系。我们进行了先验杏仁核感兴趣区(ROI)分析和多变量无偏全脑数据驱动方法。虽然没有发现杏仁核内在功能连接(IFC)与大脑行为的显著关系，但多变量全脑分析显示，一个扩展的功能回路集中在两个区域：额中回(MFG)和岛后(PI)。对这些区域的后续参数和非参数ROI分析揭示了EL和MFG之间的关系，以及PI-IFC与默认、突显和视觉网络的关系，表明高阶认知和躯体感觉过程对ASD的情绪调节至关重要。我们没有发现杏仁核IFC支持ASD患者EL的证据。然而，探索性的全脑分析发现了先前被报告为ASD异常的大规模网络。未来的研究应考虑将EL作为ASD神经元异质性的潜在来源，并将重点放在多网络相互作用上。
Autism spectrum disorder (ASD) is exceptionally heterogeneous in both clinical and physiopathological presentations. Clinical variability applies to ASD-specific symptoms and frequent comorbid psychopathology such as emotional lability (EL). To date, the physiopathological underpinnings of the co-occurrence of EL and ASD are unknown. As a first step, we examined within-ASD inter-individual variability of EL and its neuronal correlates using resting-state functional magnetic resonance imaging (R-fMRI). We analyzed R-fMRI data from 58 children diagnosed with ASD (5-12 years) in relation to the Conners' Parent Rating Scale EL index. We performed both an a priori amygdala region-of-interest (ROI) analysis, and a multivariate unbiased whole-brain data-driven approach. While no significant brain-behavior relationships were identified regarding amygdala intrinsic functional connectivity (iFC), multivariate whole-brain analyses revealed an extended functional circuitry centered on two regions: middle frontal gyrus (MFG) and posterior insula (PI). Follow-up parametric and nonparametric ROI-analyses of these regions revealed relationships between EL and MFG- and PI-iFC with default, salience, and visual networks suggesting that higher-order cognitive and somatosensory processes are critical for emotion regulation in ASD. We did not detect evidence of amygdala iFC underpinning EL in ASD. However, exploratory whole-brain analyses identified large-scale networks that have been previously reported abnormal in ASD. Future studies should consider EL as a potential source of neuronal heterogeneity in ASD and focus on multinetwork interactions.