Brain and gut interactions in irritable bowel syndrome: new paradigms and new understandings.
Brain and gut interactions in irritable bowel syndrome: new paradigms and new understandings.
复制标题
肠易激综合症中的大脑和肠相互作用：新的范式和新的理解。
DOI：
10.1007/s11894-014-0379-z
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发表时间：
2014-04
影响因子：
--
通讯作者：
Rao SS
中科院分区：
文献类型：
--
作者：
Coss-Adame E;Rao SS
肠易激综合症（IBS）的特点是腹痛和排便习惯改变。内脏过敏被认为是导致疼痛的关键潜在机制。有证据表明，IBS 中大脑和肠轴 (BGA) 内的相互作用（涉及传入上升通路和传出下降通路以及体感皮层、岛叶、杏仁核、前扣带皮层和海马体）发生紊乱，显示出激活和失活。 IBS 的临床表现，如疼痛、肠道蠕动改变和心理功能障碍，都可以部分通过 BGA 的变化来解释，但存在相互矛盾的信息，其确切作用尚未完全了解。更好地了解 BGA 可能会带来更多关于 IBS 病理生理学的知识，进而可能导致发现这种常见疾病的新疗法。
Irritable bowel syndrome (IBS) is characterized by abdominal pain and altered bowel habits. Visceral hypersensitivity is believed to be a key underlying mechanism that causes pain. There is evidence that interactions within the brain and gut axis (BGA) that involves both, the afferent-ascending and the efferent-descending pathways as well as the somatosensory cortex, insula, amygdala, anterior cingulate cortex and hippocampus are deranged in IBS showing both the activation and inactivation. Clinical manifestations of IBS such as pain, altered gut motility and psychological dysfunction may each be explained, in part through the changes in the BGA but there is conflicting information and its precise role is not fully understood. A better understanding of the BGA may shed more knowledge regarding the pathophysiology of IBS that in turn may lead to the discovery of novel therapies for this common disorder.