Two gene co-expression modules differentiate psychotics and controls.
Two gene co-expression modules differentiate psychotics and controls.
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DOI：
10.1038/mp.2012.146
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发表时间：
2013-12
影响因子：
11
通讯作者：
Liu, C.
中科院分区：
文献类型：
--
作者：
Chen, C.;Cheng, L.;Grennan, K.;Pibiri, F.;Zhang, C.;Badner, J. A.;Gershon, E. S.;Liu, C.
精神分裂症和双相情感障碍是高度可遗传的精神疾病。相关的遗传和基因表达变化已经被发现，但许多还没有被复制，功能未知。我们确定了一组表达不同的基因，即共表达模块，然后测试它们与精神分裂症的关联。利用加权基因共表达网络分析，我们发现有两个模块在患者和对照组之间存在差异表达。其中一个在大脑皮层上调，富含神经元分化和神经元发育基因，以及疾病遗传信号；第二个，在大脑皮层和小脑改变，富含参与神经元保护功能的基因。这些发现保存在五个表达数据集中，包括来自三个大脑区域的集合，来自不同微阵列平台的集合，以及来自双相情感障碍患者的集合。因此，我们认为精神分裂症和双相情感障碍的病因可能都涉及神经元的分化和发育途径，神经元保护功能参与了疾病的病理过程。
Schizophrenia and bipolar disorder are highly heritable psychiatric disorders. Associated genetic and gene expression changes have been identified, but many have not been replicated and have unknown functions. We identified groups of genes whose expressions varied together, i.e. co-expression modules, then tested them for association with schizophrenia. Using Weighted Gene Co-expression Network Analysis, we show that two modules were differentially expressed in patients versus controls. One, up-regulated in cerebral cortex, was enriched with neuron differentiation and neuron development genes, as well as disease GWAS genetic signals; the second, altered in cerebral cortex and cerebellum, was enriched with genes involved in neuron protection functions. The findings were preserved in five expression data sets, including sets from three brain regions, from a different microarray platform, and from bipolar disorder patients. From those observations, we propose neuron differentiation and development pathways may be involved in etiologies of both schizophrenia and bipolar disorder, and neuron protection function participates in pathological process of the diseases.
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WGCNA：用于加权相关网络分析的 R 包。
影响因子：
3
作者：
Langfelder P;Horvath S
通讯作者：
Horvath S
影响因子：
4.3
作者：
Langfelder P;Luo R;Oldham MC;Horvath S
通讯作者：
Horvath S
影响因子：
--
作者：
Merikangas, Kathleen R.;Akiskal, Hagop S.;Kessler, Ronald C.
通讯作者：
Kessler, Ronald C.
影响因子：
2.1
作者：
Li, Yun;Willer, Cristen J.;Ding, Jun;Scheet, Paul;Abecasis, Goncalo R.
通讯作者：
Abecasis, Goncalo R.
影响因子：
11
作者：
Lips, E. S.;Cornelisse, L. N.;Toonen, R. F.;Min, J. L.;Hultman, C. M.;Holmans, P. A.;O'Donovan, M. C.;Purcell, S. M.;Smit, A. B.;Verhage, M.;Sullivan, P. F.;Visscher, P. M.;Posthuma, D.
通讯作者：
Posthuma, D.