HETEROSEXUAL TRANSMISSION OF HIV-1 ASSOCIATED WITH THE USE OF SMOKABLE FREEBASE COCAINE (CRACK)
HETEROSEXUAL TRANSMISSION OF HIV-1 ASSOCIATED WITH THE USE OF SMOKABLE FREEBASE COCAINE (CRACK)
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DOI：
10.1097/00002030-199109000-00011
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发表时间：
1991-09-01
期刊：
影响因子：
3.8
通讯作者：
JAFFE, HW
中科院分区：
文献类型：
--
作者：
CHIASSON, MA;STONEBURNER, RL;JAFFE, HW
一项关于 HIV-1 感染危险因素的研究是在纽约市一个地区的性传播疾病诊所进行的，截至 1990 年中期，该地区成人艾滋病累计发病率为每 1000 人 9.1 人，而且使用非法药物（包括吸食游离碱可卡因（快克））很常见。志愿者中的总体血清阳性率为 12%（3084 人中的 369 人），其中 80% 的血清阳性者报告了与 HIV-1 感染相关的危险行为，包括男性间性接触、静脉注射毒品以及与静脉注射吸毒者的异性接触。否认这些风险的男性和女性血清阳性率分别为 3.6%（1389 人中的 50 人）和 4.2%（522 人中的 22 人）。在这些人中，与感染显着相关的行为是女性使用快克和卖淫，男性有梅毒史和使用快克。这些结果表明，在异性静脉注射吸毒者的 HIV-1 感染水平较高且使用快克很常见的地区，性活动的增加（包括以毒品或金钱换取性行为）可能会导致 HIV-1 的异性传播增加。
A study of risk factors for HIV-1 infection was conducted at a sexually transmitted disease clinic in an area of New York City where the cumulative incidence of AIDS in adults through mid-1990 was 9.1 per 1000 of the population and where the use of illicit drugs, including smokable freebase cocaine (crack), is common. The overall seroprevalence among volunteers was 12% (369 out of 3084), with 80% of those who were seropositive reporting risk behavior associated with HIV-1 infection, including male-to-male sexual contact, intravenous drug use and heterosexual contact with an intravenous drug user. The seroprevalence in individuals denying these risks was 3.6% (50 out of 1389) and 4.2% (22 out of 522) in men and women, respectively. Among these individuals, the behaviors significantly associated with infection were use of crack and prostitution in women, and history of syphilis and crack use in men. These results suggest that in areas where the level of HIV-1 infection in heterosexual intravenous drug users is high and the use of crack is common, increased sexual activity (including the exchange of drugs or money for sex) may result in increased heterosexual transmission of HIV-1.