Linfuranones B and C, Furanone-Containing Polyketides from a Plant-Associated Sphaerimonospora mesophila.
Linfuranones B and C, Furanone-Containing Polyketides from a Plant-Associated Sphaerimonospora mesophila.
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DOI：
10.1021/acs.jnatprod.8b00071
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发表时间：
2018-06
影响因子：
5.1
通讯作者：
Hirofumi Akiyama;Chantra Indananda;A. Thamchaipenet;Atsuko Motojima;T. Oikawa;H. Komaki;A. Hosoyama;Akane Kimura;N. Oku;Y. Igarashi
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文献类型：
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作者：
Hirofumi Akiyama;Chantra Indananda;A. Thamchaipenet;Atsuko Motojima;T. Oikawa;H. Komaki;A. Hosoyama;Akane Kimura;N. Oku;Y. Igarashi
从球孢霉属植物相关放线菌中分离得到两个新的呋喃酮类多酮化合物，分别为呋喃酮B和呋喃酮C。通过核磁共振和质谱分析确定了它们的结构，并用各向异性方法和化学降解方法确定了绝对构型。在生物合成基因的电子分析中表明，呋喃酮B是由呋喃酮C氧化裂解聚酮链而生成的。林呋喃酮B和C在20-40μM时诱导前脂肪细胞分化为成熟脂肪细胞，且无细胞毒性。
Two new furanone-containing polyketides, linfuranones B and C, were isolated from a plant-associated actinomycete of the genus Sphaerimonospora. Their structures were determined by NMR and MS spectroscopic analyses, and the absolute configurations were established by anisotropic methods and chemical degradation approaches. In silico analysis of biosynthetic genes suggested that linfuranone B is generated from linfuranone C by oxidative cleavage of the polyketide chain. Linfuranones B and C induced preadipocyte differentiation into matured adipocytes at 20-40 μM without showing cytotoxicity.