INTRINSIC GAMMA-AMINOBUTYRIC ACID NEURONS IN THE NUCLEUS OF THE SOLITARY TRACT AND THE ROSTRAL VENTROLATERAL MEDULLA OF THE RAT - AN IMMUNOCYTOCHEMICAL AND BIOCHEMICAL-STUDY
INTRINSIC GAMMA-AMINOBUTYRIC ACID NEURONS IN THE NUCLEUS OF THE SOLITARY TRACT AND THE ROSTRAL VENTROLATERAL MEDULLA OF THE RAT - AN IMMUNOCYTOCHEMICAL AND BIOCHEMICAL-STUDY
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DOI：
10.1016/0304-3940(85)90333-7
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发表时间：
1985-01-01
影响因子：
2.5
通讯作者：
REIS, DJ
中科院分区：
文献类型：
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作者：
MEELEY, MP;RUGGIERO, DA;REIS, DJ
延髓头端腹外侧 (RVL) 的 C1 肾上腺素能区的交感兴奋性神经元受到 GABA 的强直性抑制。为了确定这种 GABA 能输入的来源，通过免疫细胞化学方法测定了用秋水仙碱处理的大鼠中含有谷氨酸脱羧酶 (GAD) 的神经元的分布。许多 GAD 染色的神经元位于孤束核 (NTS) 和 RVL 中。 NTS 中的单侧损伤并未改变 RVL 中的 GABA 含量或 GAD 活性，表明从 NTS 到 RVL 的传入投射不是 GABA 能的。 RVL 中的内在 GABA 能神经元可能对 C1 区的血管运动神经元提供强直性抑制。
Sympathoexcitatory neurons in the C1 adrenergic area of the rostral ventrolateral medulla (RVL) are tonically inhibited by GABA. To identify the source of this GABAergic input, the distribution of neurons containing glutamate decarboxylase (GAD) was determined immunocytochemically in rats treated with colchicine. Numerous GAD-stained neurons were located in the nucleus of the solitary tract (NTS) and in RVL. Unilateral lesions in NTS did not alter GABA content or GAD activity in RVL, indicating that the afferent projection from NTS to RVL is not GABAergic. Intrinsic GABAergic neurons in RVL may provide tonic inhibition of vasomotor neurons in the C1 area.