Left temporal lobe dysfunction in schizophrenia -: Event-related potential and behavioral evidence from phonetic and tonal dichotic listening tasks
Left temporal lobe dysfunction in schizophrenia -: Event-related potential and behavioral evidence from phonetic and tonal dichotic listening tasks
复制标题
DOI：
10.1001/archpsyc.56.3.267
复制
发表时间：
1999-03-01
影响因子：
--
通讯作者：
Gorman, J
中科院分区：
文献类型：
--
作者：
Bruder, G;Kayser, J;Gorman, J
背景：P3事件相关电位不对称降低。（ERP）提供了精神分裂症患者左颞叶功能障碍的证据。先前的研究受限于依赖于简单的目标检测（古怪的）任务与纯音。本研究考察了双耳音节和复杂音调在双耳听音任务中的电位分布和时间进程。方法：对26例符合精神分裂症（n = 19）或精神分裂情感性障碍（n = 7）标准的患者和26例健康对照者，在两耳同时呈现不同音节或复杂音调的两种双重任务中，从30个头皮电极上记录事件相关电位。通过主成分分析，得出了与ERP波形（n1、N2、P3和晚阳性电位）重叠分量相对应的因子得分。结果：健康人右耳对双音节的感知优势明显，其左侧颞顶N2振幅大于右侧颞顶N2振幅。精神分裂症患者没有表现出这种知觉或N2不对称。与对照组相比，患者在音节和复杂音调上的后阳性电位幅度也较小，左侧颞叶部位的衰减最大。结论：健康成人在辅音-元音感知上的右耳优势与音节开始后200毫秒左侧ERP成分的峰值相关（N2）。精神分裂症患者没有表现出这些任务依赖的不对称，这可能表明参与语音分类的左颞区功能障碍。在精神分裂症患者中，一种与任务无关的后正电位的不对称减少类似于左颞叶。在听觉怪异的任务中报告了P3的减少。
Background: Asymmetric reduction of the P3 event-related potential. (ERP) has provided evidence of left temporal lobe dysfunction in schizophrenia. Prior studies have been limited by reliance on simple target detection (oddball) tasks with pure tones. This study investigated the time course and topography of ERPs to binaural syllables or complex tones in dichotic listening tasks.Methods: Event-related potentials of 26 patients meet ing criteria for schizophrenia (n = 19) or schizoaffective disorder (n = 7) and 26 healthy controls were recorded from 30 scalp electrodes during 2 dichotic tasks in which different syllables or complex tones were simultaneously presented to each ear. A principal components analysis was used to derive factor scores corresponding to overlapping components in ERP waveforms-N1, N2, P3, and a late-positive potential.Results: Healthy controls showed a right ear advantage for perceiving dichotic syllables, which was associated with greater N2 amplitude at left than right temporoparietal sites. Patients with schizophrenia did not show either this perceptual or N2 asymmetry. Patients also had smaller late-positive potential amplitude when compared with controls for both syllables and complex tones, with greatest decrement over left temporal sites.Conclusions: A right ear advantage in healthy adults for perceiving consonant-vowels was associated with a left-lateralized ERP component peaking at 200 milliseconds after syllable onset (N2). Patients with schizophrenia failed to show either of these task-dependent asymmetries, which may indicate a dysfunction of left temporal regions involved in phonetic classification. A task-independent asymmetric reduction of a later positive potential in patients with schizophrenia resembled left temporal. P3 reductions reported for auditory oddball tasks.