Prognosis of small thyroid cancer in patients with Graves' disease
Prognosis of small thyroid cancer in patients with Graves' disease
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DOI：
10.1002/bjs.5279
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发表时间：
2006-04-01
影响因子：
9.6
通讯作者：
Kawamoto, H
中科院分区：
文献类型：
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作者：
Kikuchi, S;Noguchi, S;Kawamoto, H
背景：为了寻找对小甲状腺癌（直径小于等于1cm）合并Graves病患者的最佳随访方法，本研究考察这类患者是否与无Graves病的STC患者具有同样好的预后。方法：1970 ~ 1996年，2199例甲状腺切除术后经病理诊断为STC的患者。其中，509名患者（33名男性，476名女性，平均年龄43.5岁）因Graves病接受了甲状腺切除术。对照组STC无Graves病患者的年龄、性别、治疗年份和谣言大小匹配（男性33例，女性476例，平均年龄44.0岁）。结果：合并STC和Graves的患者比单纯STC患者的无病生存期更长（20年随访时分别为99%和93%，P < 0.001）。Cox比例风险分析显示，与手术相比，伴发Graves病和手术年龄是预测无病生存的更重要因素。结论：Graves行甲状腺切除术并发STC的患者预后良好，无病生存期较单纯STC患者长。
Background: To find the best ways to follow up patients with small thyroid cancer (STC; 1 cm or less in diameter) and concomitant Graves' disease, this study examined whether such patients had the same excellent prognosis as those with STC without Graves' disease.Methods: Between 1970 and 1996, 2199 patients were diagnosed as having STC by pathology after thyroidectomy. Of those, 509 patients (33 males and 476 females, mean age 43.5 years) underwent thyroidectomy for Graves' disease. Control patients with STC without Graves' disease were matched for age, sex, treatment year and rumour size (33 males and 476 females, mean age 44.0 years).Results: Patients with STC and Graves' disease had a longer disease-free survival than those with STC alone (99 and 93 per cent at 20 years' follow-up, respectively; P < 0.001). The Cox's proportional hazard analysis showed that concomitant Graves' disease and age at surgery are more significant factors for predicting disease-free survival than surgical procedures.Conclusion: Patients who undergo thyroidectomy for Graves' disease and are found to have STC have an excellent prognosis and longer disease-free survival than patients with STC alone.