Voxel-based diffusion tensor imaging in patients with mesial temporal lobe epilepsy and hippocampal sclerosis
Voxel-based diffusion tensor imaging in patients with mesial temporal lobe epilepsy and hippocampal sclerosis
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DOI：
10.1016/j.neuroimage.2007.12.031
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发表时间：
2008-04-01
期刊：
影响因子：
5.7
通讯作者：
Duncan, John S.
中科院分区：
文献类型：
--
作者：
Focke, Niels K.;Yogarajah, Mahinda;Duncan, John S.
背景：内侧颞叶癫痫（mTLE）伴海马硬化（HS）是局灶性癫痫的重要病因。在这项研究中，我们使用扩散张量成像（DTI）和两种基于全脑体素的方法：统计参数映射（SPM）和基于束的空间统计（TBSS）来探索连接网络的完整性。33例接受术前评估的mTLE和HS连续患者在3 T下进行扫描，获得DTI数据集并计算分数各向异性（FA）和平均扩散率（MD）的参数图。21例患者有左侧海马硬化（LHS），12例患者有右侧HS（RHS）。这些组进行了比较，37名正常对照组使用SPM 5和TBSS。结果：同侧颞叶显示广泛的FA减少在两组。LHS组边缘系统明显异常，也涉及弓状束。在RHS中，变化更受限制，但也显示出对侧颞叶和下额叶的参与。SPM发现同侧海马MD增加，TBSS仅轻微检测到。然而，在白色区域，TBSS比SPM对变化更敏感。结论：DT1检测到mTLE伴HS的广泛变化。受影响的网络主要在同侧颞叶和边缘系统，但也弓状束。SPM和TBSS提供了互补的信息，对TBSS的FA变化具有更高的敏感性。(c)2008年爱思唯尔公司All rights reserved.
Background: Mesial temporal lobe epilepsy (mTLE) with hippocampus sclerosis (HS) is an important cause for focal epilepsy. In this study, we explored the integrity of connecting networks using diffusion tensor imaging (DTI) and two whole-brain voxel-based methods: statistical parametric mapping (SPM) and tract-based spatial statistics (TBSS).Methods: Thirty-three consecutive patients with mTLE and HS undergoing presurgical evaluation were scanned at 3 T, a DTI data set was acquired and parametric maps of fractional anisotropy (FA) and mean diffusivity (MD) were calculated. Twenty-one patients had left hippocampal sclerosis (LHS) and 12 patients had right HS (RHS). These groups were compared to 37 normal control subjects using both SPM5 and TBSS.Results: The ipsilateral temporal lobe showed widespread FA reduction in both groups. The limbic system was clearly abnormal in the LHS group, also involving the arcuate fasciculus. In RHS, changes were more restricted but also showed involvement of the contralateral temporal and inferior frontal lobe. Increased MD was found in the ipsilateral hippocampus by SPM that was only marginally detected by TBSS. In white matter regions, however, TBSS was more sensitive to changes than SPM.Conclusion: DT1 detects extensive changes in mTLE with HS. The affected networks were principally in the ipsilateral temporal lobe and the limbic system but also the arcuate fasciculus. SPM and TBSS gave complementary information with higher sensitivity to FA changes using TBSS. (c) 2008 Elsevier Inc. All rights reserved.