Signal transduction and Th17 cell differentiation.
Signal transduction and Th17 cell differentiation.
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DOI：
10.1016/j.micinf.2009.04.007
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发表时间：
2009-04
影响因子：
5.8
通讯作者：
Fan S
中科院分区：
文献类型：
--
作者：
O'Shea JJ;Steward-Tharp SM;Laurence A;Watford WT;Wei L;Adamson AS;Fan S
效应T辅助细胞分化为Th1或Th2谱系的范例已经被选择性地产生白介素17的第三种细胞谱系的发现所显著动摇。对这个被称为Th17的新亚群的表征，为免疫调节、宿主防御和自身免疫性疾病的发病机制提供了令人兴奋的新见解。此外，这一T细胞亚群的发现为谱系承诺和终末分化等概念提供了一个新的视角。控制这些过程的转录调控事件和表观遗传修饰是多样和复杂的，尽管数据继续以快速的速度积累，但许多问题仍有待回答。在这里，我们回顾了我们目前对导致Th17分化和效应器功能的信号通路、分子相互作用和转录事件的理解，以及伴随它们的表观遗传修饰。
The paradigm of effector T helper cell differentiation into either Th1 or Th2 lineages has been notably shaken by the discovery of a third lineage of cells that selectively produce interleukin (IL)-17. Characterization of this new subset, referred to as Th17, has provided exciting new insights into immunoregulation, host defense and the pathogenesis of autoimmune diseases. Additionally, the discovery of this T cell subset has offered a fresh look at such concepts as lineage commitment and terminal differentiation. The transcriptional regulatory events and epigenetic modifications that control these processes are diverse and complex, and despite the rapid pace at which data continues to accumulate, many questions remain to be answered. Here we review our current understanding of the signaling pathways, molecular interactions and transcriptional events that lead to Th17 differentiation and effector function, as well as the epigenetic modifications that accompany them.
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DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Santarlasci V;Maggi L;Liotta F;Mazzinghi B;Parente E;Filì L;Ferri S;Frosali F;Giudici F;Romagnani P;Parronchi P;Tonelli F;Maggi E;Romagnani S
通讯作者：
Romagnani S
影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
20.3
作者：
Chizzolini, Carlo;Chicheportiche, Rachel;Dayer, Jean-Michel
通讯作者：
Dayer, Jean-Michel
DOI：
10.1073/pnas.0600666103
发表时间：
2006-05-23
影响因子：
11.1
作者：
Chen, Zhi;Laurence, Arian;O'Shea, John J.
通讯作者：
O'Shea, John J.