Chronic oxidative stress induces a tissue-specific reduction in telomere length in CAST/Ei mice
Chronic oxidative stress induces a tissue-specific reduction in telomere length in CAST/Ei mice
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DOI：
10.1016/j.freeradbiomed.2008.01.007
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发表时间：
2008-04-15
影响因子：
7.4
通讯作者：
Lacolley, Patrick
中科院分区：
文献类型：
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作者：
Cattan, Valerie;Mercier, Nathalie;Lacolley, Patrick
我们研究体内氧化应激增加是否会促进CAST/Ei小鼠的端粒缩短。我们探讨了L-丁硫氨酸亚砜处理（BSO）对端粒长度的影响。BSO缩短了白色脂肪、棕色脂肪、皮肤、尾部和睾丸中的端粒长度，同时降低了组织谷胱甘肽含量，增加了组织羰基含量，并增加了血浆晚期氧化蛋白产物。端粒酶活性主要在睾丸中检测到，但没有观察到端粒酶活性在BSO反应中降低。总之，BSO介导的全身氧化应激增加缩短了小鼠几种组织中的端粒。BSO处理对不同组织端粒长度的影响不同，可能是由于它们的适应性抗氧化能力不同。(c)2008年爱思唯尔公司All rights reserved.
We examine whether increased oxidative stress in vivo promotes telomere shortening in CAST/Ei mice. We explored the effects of L-buthionine sulfoximine treatment (BSO) on telomere length. BSO shortened telomere length in white fat, brown fat, skin, tail, and testis in concert with diminished tissue glutathione content, increased tissue carbonyl content, and increased plasma advanced oxidized protein products. Telomerase activity was mainly detected in testis but no reduction of telomerase activity was observed in response to BSO. In conclusion, BSO-mediated increase in systemic oxidative stress shortens telomeres in several tissues of the mouse. The variable effect of BSO treatment on telomere length in different tissue may result from their different adaptive antioxidative capacity. (c) 2008 Elsevier Inc. All rights reserved.