Role of endogenous retroviruses in autoimmune diseases
Role of endogenous retroviruses in autoimmune diseases
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DOI：
10.1016/j.idc.2006.09.008
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发表时间：
2006-12-01
影响因子：
4.4
通讯作者：
Garry, Robert F.
中科院分区：
文献类型：
--
作者：
Colmegna, Ines;Garry, Robert F.
人类基因组测序计划和其他物种的类似计划已经揭示，脊椎动物基因组DNA的很大一部分由存在于多个拷贝中的遗传元件组成。人内源性逆转录病毒（HERV）代表一类称为逆转录转座子的散布的移动的重复元件。HERV与逆转录病毒科的某些成员密切相关，逆转录病毒科是人类和动物病毒的重要家族，包括艾滋病毒和人类嗜T淋巴细胞病毒，分别是艾滋病和成人T细胞白血病的病因。最近的研究表明HERV参与了多种病理和生理过程。本文讨论了与许多人类自身免疫性疾病有关的研究。
The human genome sequencing project and similar initiatives for other species have revealed that a large portion of vertebrate genomic DNA consists of genetic elements that are present in multiple copies. Human endogenous retroviruses (HERVs) represent a class of interspersed mobile repetitive elements known as retrotransposons. HERVs are closely related to certain members of the Retroviridae, an important family of human and animal viruses that includes HIV and human T-lymphotropic virus, causes of AIDS and adult T-cell leukemia, respectively. Recent studies have implicated HERVs in a wide variety of pathologic and physiologic processes. This article discusses studies that implicate HERVs in many human autoimmune diseases.