T helper cell differentiation in immune response.
T helper cell differentiation in immune response.
复制标题
免疫反应中辅助 T 细胞的分化。
DOI：
10.1016/0952-7915(95)80111-1
复制
发表时间：
1995
影响因子：
7
通讯作者：
Seder,RA
中科院分区：
文献类型：
--
作者：
Reiner,SL;Seder,RA
在了解抗原特异性CD4+T辅助细胞反应的成熟方面取得了重大进展。最近的研究进展集中在细胞因子、辅助分子和细胞类型的网络上，这些网络塑造了不同T辅助细胞亚群的分化。转基因和基因敲除小鼠的使用以及充分表征的体内模型有助于阐明许多这些复杂因素的相互依赖或独立。
Significant progress has been made in understanding the maturation of antigen-specific CD4+T helper cell responses. Recent progress centers on the network of cytokines, accessory molecules, and cell types that shapes the differentiation of distinct T helper cell subsets. Use of transgenic and knockout mice and well characterized in vivo models have helped clarify the interdependence or independence of many of these complex factors.