Circulating CD14+HLA-DR-/low myeloid-derived suppressor cells predicted early recurrence of hepatocellular carcinoma after surgery
Circulating CD14+HLA-DR-/low myeloid-derived suppressor cells predicted early recurrence of hepatocellular carcinoma after surgery
复制标题
循环CD14 HLA-DR-/低骨髓源性抑制细胞预测肝细胞癌术后早期复发。
DOI：
10.1111/hepr.12831
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发表时间：
2017-09-01
影响因子：
4.2
通讯作者：
Yang, Xin-Rong
中科院分区：
文献类型：
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作者：
Gao, Xing-Hui;Tian, Lu;Yang, Xin-Rong
目的骨髓源性抑制细胞（MDSC）在肿瘤进展中起重要作用。本研究的目的是探讨MDSCs对肝细胞癌（HCC）早期复发患者进行根治性切除术的预后价值。MethodsMyeloid-derived suppressor cells通过流式细胞术测定。使用2014年2月至2015年7月期间接受根治性切除术的183名患者队列分析了MDSC与肿瘤复发之间的相关性。使用Kaplan-Meier生存估计和log-rank tests.ResultsIn vivo，CD 14（+）HLA-DR-/low MDSCs抑制T细胞增殖和分泌。CD 14（+）HLA-DR-/low MDSCs在HCC患者中的频率（3.7 ± 5.3%，n=183）显著高于慢性肝炎患者（1.4 ± 0.6%，n=25）和健康对照（1.1 ± 0.5%，n=50）。MDSC的高频率与复发（至复发的时间）显著相关（P
AimMyeloid-derived suppressor cells (MDSCs) play an important role in tumor progression. The aim of the present study was to investigate the prognostic value of MDSCs for early recurrence of hepatocellular carcinoma (HCC) in patients undergoing curative resection.MethodsMyeloid-derived suppressor cells were measured by flow cytometry. The correlation between MDSCs and tumor recurrence was analyzed using a cohort of 183 patients who underwent curative resection between February 2014 and July 2015. Prognostic significance was further assessed using Kaplan-Meier survival estimates and log-rank tests.ResultsIn vivo, CD14(+)HLA-DR-/low MDSCs inhibit T cell proliferation and secretion. The frequency of CD14(+)HLA-DR-/low MDSCs was significantly higher in HCC patients (3.75.3%, n=183) than in chronic hepatitis patients (1.4 +/- 0.6%, n=25) and healthy controls (1.1 +/- 0.5%, n=50). High frequency of MDSCs was significantly correlated with recurrence (time to recurrence) (P