The Association of Statin Use and Statin Type and Cognitive Performance: Analysis of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study
The Association of Statin Use and Statin Type and Cognitive Performance: Analysis of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study
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DOI：
10.1002/clc.20758
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发表时间：
2010-05-01
影响因子：
2.7
通讯作者：
Howard, George
中科院分区：
文献类型：
--
作者：
Glasser, Stephen P.;Wadley, Virginia;Howard, George
背景：他汀类药物的使用和类型与认知功能受损或改善相关。假设：评估他汀类药物的使用与（亲脂性vs亲水性）和认知障碍。对24595名参与者的横断面分析（7191名他汀类药物使用者和17404名非使用者）年龄≥ 45岁，来自一项基于人群的国家队列研究（中风的地理和种族差异的原因）在2003年1月至2008年10月期间招募，从东南部中风带和非洲裔美国人中过度抽样。他汀类药物的使用和类型由训练有素的健康专业人员在参与者家中记录。认知性能进行了评估与先前验证的工具的整体认知状态（六项筛选）。认知障碍定义为以下评分：
Background: Statin use and type have been variably associated with impaired or improved cognitive performance. Hypothesis: To assess the association of statin use and type (lipophilic vs hydrophilic) and cognitive impairment.Methods: Cross-sectional analysis of 24 595 participants (7191 statin users and 17 404 nonusers) age >= 45 years, from a population-based national cohort study (Reasons for Geographic And Racial Differences in Stroke) enrolled between January 2003 and October 2008, with oversampling from the southeastern Stroke Belt and African Americans. Statin use and type were documented in participants' homes by a trained health professional. Cognitive performance was assessed with a prior validated instrument of global cognitive status (Six-Item Screener). Cognitive impairment was defined as a score of