The filamins Organizers of cell structure and function
The filamins Organizers of cell structure and function
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DOI：
10.4161/cam.5.2.14401
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发表时间：
2011-03-01
影响因子：
3.2
通讯作者：
Hartwig, John H.
中科院分区：
文献类型：
--
作者：
Nakamura, Fumihiko;Stossel, Thomas P.;Hartwig, John H.
纤维蛋白A （Filamin A, FLNa）是1975年发现的第一个非肌动蛋白丝交联蛋白。35年的FLNa研究揭示了其结构的细节，发现了其异构体（FLNb和c），并确定了90多种结合伙伴，包括通道，受体，细胞内信号分子，甚至转录因子。由于这种多样性，人类FLN基因的突变导致广泛的异常，具有中度到致命的后果。本文就FLNa在细胞迁移和粘附中的结构和功能作一综述。
Filamin A (FLNa), the first non-muscle actin filament cross-linking protein, was identified in 1975. Thirty-five years of FLNa research has revealed its structure in great detail, discovered its isoforms (FLNb and c), and identified over 90 binding partners including channels, receptors, intracellular signaling molecules, and even transcription factors. Due to this diversity, mutations in human FLN genes result in a wide range of anomalies with moderate to lethal consequences. This review focuses on the structure and functions of FLNa in cell migration and adhesion.