Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients.
Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients.
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DOI：
10.1080/2162402x.2021.1873585
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发表时间：
2021-02-02
期刊：
影响因子：
7.2
通讯作者：
Speiser DE
中科院分区：
文献类型：
--
作者：
de Jonge K;Tillé L;Lourenco J;Maby-El Hajjami H;Nassiri S;Racle J;Gfeller D;Delorenzi M;Verdeil G;Baumgaertner P;Speiser DE
对 B 细胞在实体瘤患者中的作用的了解仍然不足。我们发现循环 B 细胞产生 TNFα 和/或 IL-6，与接受抗 CTLA4 抗体治疗的黑色素瘤患者无反应和较差的总体生存率相关。黑色素瘤转移 B 细胞的转录组分析显示炎症反应基因表达丰富。来自肿瘤微环境的公开单 B 细胞数据揭示了 TNFα 表达与免疫检查点阻断反应之间存在负相关。这些发现表明 B 细胞通过产生炎症细胞因子促进肿瘤生长。这些 B 细胞可能与三级淋巴结构相关的 B 细胞不同，后者被描述为与癌症患者良好的临床结果相关。需要进一步的研究来识别和表征 B 细胞亚群及其促进或抑制肿瘤生长的功能，目的是识别生物标志物和新的治疗靶点。
The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with anti-CTLA4 antibody. Transcriptome analysis of B cells from melanoma metastases showed enriched expression of inflammatory response genes. Publicly available single B cell data from the tumor microenvironment revealed a negative correlation between TNFα expression and response to immune checkpoint blockade. These findings suggest that B cells contribute to tumor growth via the production of inflammatory cytokines. Possibly, these B cells are different from tertiary lymphoid structure-associated B cells, which have been described to correlate with favorable clinical outcome of cancer patients. Further studies are required to identify and characterize B cell subsets and their functions promoting or counteracting tumor growth, with the aim to identify biomarkers and novel treatment targets.