THEORY OF HIGH-RESOLUTION MASS-SPECTROMETRY ACHIEVED VIA RESONANCE EJECTION IN THE QUADRUPOLE ION TRAP
THEORY OF HIGH-RESOLUTION MASS-SPECTROMETRY ACHIEVED VIA RESONANCE EJECTION IN THE QUADRUPOLE ION TRAP
复制标题
DOI：
10.1021/ac00037a023
复制
发表时间：
1992-07-01
影响因子：
7.4
通讯作者：
GLISH, GL
中科院分区：
文献类型：
--
作者：
GOERINGER, DE;WHITTEN, WB;GLISH, GL
从四极离子阱中离子运动的赝势阱近似出发，导出了离子共振喷射线形状的解析表达式。结合离子-分子碰撞和共振激发频率随时间的线性变化的术语，可以计算线形，并显示为扫描速率和弛豫时间的函数。推导质量和频线宽度之间的关系，可以将质量分辨率作为基本离子阱工作参数的函数进行评估。研究结果解释了共振弹射与延迟扫描速率相结合时对分辨率的协同效应，并表明对于任何非零扫描速率，存在一个与分辨率最大值对应的最佳碰撞阻尼值。实验变量质量/电荷、中性压力和扫描速率对模型质量分辨率和精度的影响也进行了评估，并在方便的图表中说明。
Beginning with the pseudopotential well approximation for ion motion in the quadrupole ion trap, analytical expressions are derived for the ion resonance ejection line shape. Incorporation of terms for ion-molecule collisions and linear variation with time of the resonance excitation frequency enables line shapes to be calculated and displayed as a function of scan rate and relaxation time. Derivation of the relationship between mass and frequency line widths allows the mass resolution to be evaluated as a function of fundamental ion trap operating parameters. The results account for the synergistic effect on resolution when resonance ejection is combined with retarded scan rates and indicate that for any non-zero scan rate there is an optimum collisional damping value corresponding to a resolution maximum. The effects of the experimental variables mass/charge, neutral pressure, and scan rates on mass resolution and accuracy are also evaluated in terms of the model and illustrated In convenient plots.