Benzothiazines in synthesis: Studies directed toward the synthesis of erogorgiaene
Benzothiazines in synthesis: Studies directed toward the synthesis of erogorgiaene
复制标题
DOI：
10.1021/jo701935s
复制
发表时间：
2008-02-15
影响因子：
3.6
通讯作者：
Schreiner, Peter R.
中科院分区：
文献类型：
--
作者：
Harmata, Michael;Hong, Xuechuan;Schreiner, Peter R.
本文叙述了苯并噻嗪类化合物在罗汉果烯的形式全合成中的应用以及该天然产物两种非对映体的立体选择性全合成。特别是，stereochernical过程中的自由基环化预期得到正确的相对立体化学的erogorgiaene的合成进行了讨论，利用实验和计算数据。
The use of benzothiazenes for the formal total synthesis of erogoroiaene and stereoselective total syntheses of two diastereomers of this natural product is described. In particular, the stereochernical course of a radical cyclization anticipated to give the correct relative stereochemistry for the synthesis of erogorgiaene is discussed utilizing both experimental and computational data.